نتایج جستجو برای: atl granzyme htlv

تعداد نتایج: 10406  

Objective(s): Human T cell leukaemia virus type 1 (HTLV-1) is associated with adult T cell leukaemia (ATL), a malignant lymphoproliferative disease that infects CD4 T cells. It is not clear why the majority of HTLV-1-infected individuals remain asymptomatic carries (ACs) and a minority develop ATL. Cellular immune response has a critical role in ATL and destroys malign...

2017
Alison K. Esser Daniel A. Rauch Jingyu Xiang John C. Harding Nicole A. Kohart Michael H. Ross Xinming Su Kevin Wu Devra Huey Yalin Xu Kiran Vij Patrick L. Green Thomas J. Rosol Stefan Niewiesk Lee Ratner Katherine N. Weilbaecher

Adult T-cell leukemia/lymphoma (ATL) is an aggressive T cell malignancy that occurs in HTLV-1 infected patients. Most ATL patients develop osteolytic lesions and hypercalcemia of malignancy, causing severe skeletal related complications and reduced overall survival. The HTLV-1 virus encodes 2 viral oncogenes, Tax and HBZ. Tax, a transcriptional activator, is critical to ATL development, and has...

Journal: :Renal Replacement Therapy 2023

Abstract Backgrounds Therefore, reports on the risk of HTLV-1-related diseases in organ transplantation have increased recent years, and management HTLV renal remains a challenge. Patients methods We retrospectively analyzed four HTLV-1-positive recipients or donors among 89 cases from 2006 to 2021. Results Among recipients, two patients developed adult T cell leukemia/lymphoma (ATL) derived at...

2017
Huseini H. Kagdi Maria A. Demontis Paul A. Fields Juan Carlos Ramos Charles R. M. Bangham Graham P. Taylor

Adult T-cell leukemia/lymphoma (ATL), a human T-lymphotropic virus type 1 (HTLV-1)-associated disease, has a highly variable clinical course and four subtypes with therapeutic and prognostic implications. However, there are overlapping features between ATL subtypes and between ATL and nonmalignant (non-ATL) HTLV-1 infection complicating diagnosis and prognostication. To further refine the diagn...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1986
M Shimoyama Y Kagami K Shimotohno M Miwa K Minato K Tobinai K Suemasu T Sugimura

We describe five patients with adult T-cell leukemia/lymphoma (ATL) with neither integration of human T-cell leukemia virus type I (HTLV-I) into their leukemia cells nor anti-HTLV-I antibody in their sera. These findings indicate that HTLV-I may not have been involved in leukemogenesis in these patients. The clinicohematological, cytopathological, and immunological features of HTLV-I-negative A...

2012
Masako Iwanaga Toshiki Watanabe Kazunari Yamaguchi

Adult T-cell leukemia (ATL) is an aggressive T-cell malignancy caused by human T-cell leukemia virus type I (HTLV-1) infection and often occurs in HTLV-1-endemic areas, such as southwestern Japan, the Caribbean islands, Central and South America, Intertropical Africa, and Middle East. To date, many epidemiological studies have been conducted to investigate the incidence of ATL among general pop...

Journal: :Cureus 2023

Adult T-cell lymphoma (ATL) is a hematological malignancy of CD4+ mature T-lymphocytes commonly associated with chronic human T-lymphotropic virus type I (HTLV-1) infection. Chronic HTLV-1 infection induces oncogenic mutations in T-cells, leading to an acute malignant transformation host cells. Atypically, ATL presents dermatological and pulmonary symptoms consistent “smoldering” disease patter...

2013
Mohammad Mehdi Akbarin Hossein Rahimi Tahereh HassanNia Ghazaleh Shoja Razavi Faezeh Sabet Abbas Shirdel

OBJECTIVE(S) Human T Lymphocyte Virus Type one (HTLV-I) is a retrovirus that infects about 10-20 million people worldwide. Khorasan province in Iran is an endemic area. The majority of HTLV-I-infected individuals sustain healthy carriers but small proportion of infected population developed two progressive diseases: HAM/TSP and ATL. The proviral load could be a virological marker for disease mo...

Journal: :EJHaem 2023

Viral cell-free DNA (cfDNA) in plasma has been widely evaluated for detecting cancer and monitoring disease virus-associated tumors. We investigated whether the amount of cfDNA human T-cell leukemia virus type 1 (HTLV-1) correlates with state adult leukemia-lymphoma (ATL). HTLV-1 aggressive ATL was significantly higher than that indolent asymptomatic carriers. Notably, patients lymphoma represe...

Journal: :Journal of virology 1995
G Feuer S A Stewart S M Baird F Lee R Feuer I S Chen

Human T-cell leukemia virus (HTLV) is the etiologic agent of adult T-cell leukemia (ATL), a malignancy of T lymphocytes that is characterized by a long latency period after virus exposure. Intraperitoneal inoculation of severe combined immunodeficient (SCID) mice with HTLV-transformed cell lines and ATL tumor cells was employed to investigate the tumorigenic potential of HTLV type I (HTLV-I)-in...

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