نتایج جستجو برای: atl granzyme htlv

تعداد نتایج: 10406  

Journal: :Revista panamericana de salud publica = Pan American journal of public health 2006
Anna Bárbara F Carneiro-Proietti Bernadette C Catalan-Soares Carlos M Castro-Costa Edward L Murphy Ester C Sabino Michie Hisada Bernardo Galvão-Castro Luiz C J Alcantara Carlo Remondegui Kristien Verdonck Fernando A Proietti

The first description of the human T-lymphotropic virus type 1 (HTLV-1) was made in 1980, followed closely by the discovery of HTLV-2, in 1982. Since then, the main characteristics of these viruses, commonly referred to as HTLV-1/2, have been thoroughly studied. Central and South America and the Caribbean are areas of high prevalence of HTLV-1 and HTVL-2 and have clusters of infected people. Th...

Journal: :Viruses 2016
Jessica L Martin José O Maldonado Joachim D Mueller Wei Zhang Louis M Mansky

Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered. Studies on HTLV-1 have been instrumental for our understanding of the molecular pathology of virus-induced cancers. HTLV-1 is the etiological agent of an adult T-cell leukemia (ATL) and can lead to a variety of neurological pathologies, including HTLV-1-associated-myelopathy/tropical spastic paraparesis (HAM/...

Journal: :Blood 1994
M Fujita K Murata H Shiku

Adult T-cell leukemia (ATL), a disorder associated with high mortality rates, arises from human T-lymphotropic virus type I (HTLV-I)-infected CD4+ T cells. We designed a retroviral vector-based gene therapy approach to ATL. The long terminal repeat (LTR) of HTLV-I is transactivated by the viral tax protein. We constructed a hybrid gene consisting of herpes simplex virus thymidine kinase (HSV TK...

Journal: :International journal of oncology 2015
Chie Ishikawa Masachika Senba Betsy J Barnes Naoki Mori

Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia (ATL), an aggressive and fatal leukemia of T cells. Interferon regulatory factor (IRF)-5 plays a critical role in the induction of interferon genes in viral infected cells. We examined the specific mechanisms underlying the expression and regulation of IRF-5 in HTLV-1-infected T cells. IRF-5 was constitu...

Journal: :Journal of virology 2005
Takehiro Matsuda Alex Almasan Mariko Tomita Jun-nosuke Uchihara Masato Masuda Kazuiku Ohshiro Nobuyuki Takasu Hideo Yagita Takao Ohta Naoki Mori

Adult T-cell leukemia (ATL), a CD4+-T-cell malignancy caused by human T-cell leukemia virus type 1 (HTLV-1), is difficult to cure, and novel treatments are urgently needed. Apo2 ligand (Apo2L; also tumor necrosis factor-related apoptosis-inducing ligand [TRAIL]) has been implicated in antitumor therapy. We found that HTLV-1-infected T-cell lines and primary ATL cells were more resistant to Apo2...

2013
Seiichiro Kobayashi Yamin Tian Nobuhiro Ohno Koichiro Yuji Tomohiro Ishigaki Masamichi Isobe Mayuko Tsuda Naoki Oyaizu Eri Watanabe Nobukazu Watanabe Kenzaburo Tani Arinobu Tojo Kaoru Uchimaru

PURPOSE In a recent study to purify adult T-cell leukemia-lymphoma (ATL) cells from acute-type patients by flow cytometry, three subpopulations were observed in a CD3 versus CD7 plot (H: CD3(high)CD7(high); D: CD3(dim)CD7(dim); L: CD3(dim)CD7(low)). The majority of leukemia cells were enriched in the L subpopulation and the same clone was included in the D and L subpopulations, suggesting clona...

Journal: :Blood 1985
K Kinoshita T Amagasaki S Ikeda J Suzuyama K Toriya K Nishino M Tagawa M Ichimaru S Kamihira Y Yamada

We report the clinical, hematologic, and immunologic features of 18 preleukemic adult T cell leukemia (pre-ATL) cases with abnormal T lymphocytosis induced by human adult T cell leukemia-lymphoma virus (HTLV/ATLV). The patients were from the Nagasaki district, which is one of the most endemic areas of ATL in Japan. Pre-ATL is a subclinical T cell abnormality differing from ATL. It is characteri...

Journal: :American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012
D R Kaul

Human T cell lymphotrophic Virus 1 (HTLV-1) is endemic in the Caribbean, parts of South America, West Africa, Asia and Oceania but rare in North America. After a prolonged latency, HTLV-1 is associated with development of acute T cell leukemia/lymphoma (ATL) in 2–5% of infected individuals and HTLV-1-associated myelopathy (HAM) in a smaller percentage. Screening tests do not distinguish between...

Journal: :Blood 1991
A Okayama B Korber Y M Chen J Allan T H Lee S Shioiri N Tachibana K Tsuda N Mueller M F McLane

Detection methods for the human T-cell leukemia virus type-I (HTLV-I) for blood screening and diagnosis generally rely on antibody tests that use the structural proteins of HTLV-I as antigen. We have found an unusual pattern of antibody reactivity among people who are at high risk of HTLV infection due to being a family member of an adult T-cell leukemia (ATL) patient: a specific antibody react...

2007
M. Tomita G. L. Semenza C. Michiels T. Matsuda J.-N. Uchihara T. Okudaira Y. Tanaka N. Taira K. Ohshiro N. Mori

HTLV-1 (human T-cell leukaemia virus type 1) is the causative agent for ATL (adult T-cell leukaemia). HTLV-1 Tax can activate the PI3K (phosphoinositide 3-kinase)/Akt signalling pathway, which is responsible for survival of HTLV-1-infected T-cells. HIFs (hypoxia-inducible factors) are transcriptional regulators that play a central role in the response to hypoxia. Overexpression of HIF-1alpha in...

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