نتایج جستجو برای: atl granzyme htlv

تعداد نتایج: 10406  

Journal: :Blood 1987
N Mori P S Gill T Mougdil S Murakami S Eto D Prager

We studied the serum levels of interleukin-10 (IL-10), in patients with adult T-cell leukemia (ATL) caused by human T-cell leukemia virus type I (HTLV-I) infection. Elevated IL-10 levels were observed in 33 of 45 patients with ATL. Fresh leukemic cells from ATL patients as well as HTLV-I-infected T-cell lines MT-2, SLB-1, and C10/MJ expressed IL-10 mRNA by reverse transcription-polymerase chain...

Journal: :Carcinogenesis 2006
Yulia Tabakin-Fix Inbal Azran Yana Schavinky-Khrapunsky Oren Levy Mordechai Aboud

Human T-cell leukemia virus type 1 (HTLV-I) has been implicated with the etiology of adult T-cell leukemia (ATL) and certain other clinical disorders. Although the leukemogenic mechanism of HTLV-1 is not fully understood yet, the viral Tax protein is widely regarded as a key factor in this mechanism. Tax can modulate the synthesis or function of many regulatory factors which control a wide rang...

2017
Yasunori Kogure Keisuke Kataoka

Adult T-cell leukemia/lymphoma (ATL) is a peripheral T-cell neoplasm with a dismal prognosis. It is caused by human T-cell leukemia virus type-1 (HTLV-1) retrovirus. A long latency period from HTLV-1 infection to ATL onset suggests that not only HTLV-1 proteins, such as Tax and HBZ, but also additional genetic and/or epigenetic events are required for ATL development. Although many studies have...

Journal: :The Journal of Experimental Medicine 1985
M Maeda A Shimizu K Ikuta H Okamoto M Kashihara T Uchiyama T Honjo J Yodoi

Using the clone-specific rearrangement of the T cell receptor gene as the genetic marker of the clonotype, we analyzed the clonal origin of the interleukin 2 (IL-2)-dependent human T-lymphotrophic virus I (HTLV-I)-positive T cell lines established from various adult T cell leukemia (ATL) patients. From a patient with chronic ATL, whose leukemic cells proliferated in vitro in response to IL-2, w...

Journal: :Blood 2017
Toshiki Watanabe

Adult T-cell leukemia (ATL) is an aggressive T-cell malignancy caused by human T-cell leukemia virus type 1 (HTLV-1) that develops through a multistep carcinogenesis process involving 5 or more genetic events. We provide a comprehensive overview of recently uncovered information on the molecular basis of leukemogenesis in ATL. Broadly, the landscape of genetic abnormalities in ATL that include ...

2015
Seiichiro Kobayashi Eri Watanabe Tomohiro Ishigaki Nobuhiro Ohno Koichiro Yuji Kazumi Nakano Tadanori Yamochi Nobukazu Watanabe Arinobu Tojo Toshiki Watanabe Kaoru Uchimaru

We previously reported that the cell adhesion molecule 1 (CADM1) versus CD7 plot in flow cytometry reflects disease progression in human T-cell leukemia virus type 1 (HTLV-1) infection. In CD4(+) cells from peripheral blood, CADM1(-) CD7(+) (P), CADM1(+) CD7(dim) (D) and CADM1(+) CD7(-) (N) subpopulations are observed. The D and N subpopulations increase as asymptomatic HTLV-1 carriers (AC) pro...

Journal: :Archivum immunologiae et therapiae experimentalis 2005
Cynthia A Pise-Masison Soo-Jin Jeong John N Brady

Human T cell leukemia virus type 1 (HTLV-1) is a complex human retrovirus which is the causative agent of adult T cell leukemia (ATL). ATL occurs in about 4% of carriers and develops after a long latent period. Although the precise mechanism of HTLV-1 oncogenesis remains unclear, the pathogenesis has been linked to the pleiotropic activity of the viral transcriptional activator protein Tax. Tax...

2011
Natsumi Araya Tomoo Sato Naoko Yagishita Hitoshi Ando Atae Utsunomiya Steven Jacobson Yoshihisa Yamano

Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that is the causative agent of adult T cell leukemia/lymphoma (ATL) and associated with multiorgan inflammatory disorders, including HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and uveitis. HTLV-1-infected T cells have been hypothesized to contribute to the development of these disorders, although the precise mec...

2015
Takayuki Takachi Masahiko Takahashi Manami Takahashi-Yoshita Masaya Higuchi Miki Obata Yukio Mishima Shujiro Okuda Yuetsu Tanaka Masao Matsuoka Akihiko Saitoh Patrick L Green Masahiro Fujii

Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T cell leukemia (ATL), which is an aggressive form of T-cell malignancy. HTLV-1 oncoproteins, Tax and HBZ, play crucial roles in the immortalization of T-cells and/or leukemogenesis by dysregulating the cellular functions in the host. Recent studies show that HTLV-1-infected T-cells have reduced expression of the BCL1...

Journal: :Clinical Chemistry 2023

Abstract Background The human T-cell lymphotropic virus (HTLV) infects a type of white blood cell called or T-lymphocyte. There are two types HTLV, HTLV-I and HTLV-II, which closely related to C retroviruses. is endemic in the Caribbean, Japan, South America, parts Africa. has been recognized as cause adult leukemia (ATL) HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-I...

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