نتایج جستجو برای: atl granzyme htlv

تعداد نتایج: 10406  

2014
Seiichiro Kobayashi Kazumi Nakano Eri Watanabe Tomohiro Ishigaki Nobuhiro Ohno Koichiro Yuji Naoki Oyaizu Satomi Asanuma Makoto Yamagishi Tadanori Yamochi Nobukazu Watanabe Arinobu Tojo Toshiki Watanabe Kaoru Uchimaru

Purpose:Cell adhesionmolecule 1 (CADM1), initially identified as a tumor suppressor gene, has recently been reported to be ectopically expressed in primary adult T-cell leukemia–lymphoma (ATL) cells. We incorporated CADM1 into flow-cytometric analysis to reveal oncogenic mechanisms in human T-cell lymphotrophic virus type I (HTLV-I) infection by purifying cells from the intermediate stages of ATL

2018
Stefania Fochi Simona Mutascio Umberto Bertazzoni Donato Zipeto Maria G. Romanelli

Human T-cell lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL), an aggressive CD4+/CD25+ T-cell malignancy and of a severe neurodegenerative disease, HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). The chronic activation or deregulation of the canonical and non-canonical nuclear factor kappa B (NF-κB) pathways play a crucial role in tu...

Journal: :Blood 1997
N Mori F Kashanchi D Prager

Human T-cell leukemia virus type-I (HTLV-I), the etiologic agent of adult T-cell leukemia (ATL) transforms human T cells both in vivo and in vitro. However, the long latency period between infection and development of ATL, as well as the small fraction of the infected population that actually develops this disease, suggest that factors in addition to the virus are involved in its pathogenesis. ...

2013
Ali Shoeibi Mohammdmahdi Etemadi Amir Moghaddam Ahmadi Mona Amini Reza Boostani

Human T-cell lymphotropic virus (HTLV) types 1 and 2 belong to the Oncorna group of retroviridae, a large family of viruses, grouped initially by pathogenic features, but later revised on the basis of genome structure and nucleotide sequence. HTLV-I was the first discovered human retrovirus to be associated with a malignancy in 1980. The malignancy, first described by Uchiyama and co-workers in...

2017
Marco Baratella Greta Forlani Roberto S. Accolla

Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic human retrovirus that has infected 10-15 million people worldwide. After a long latency, 3-5% of infected individuals will develop either a severe malignancy of CD4+ T cells, known as Adult T-cell Leukemia (ATL) or a chronic and progressive inflammatory disease of the nervous system designated Tropical Spastic Paraparesis/HTLV-1-Associ...

2014
RYUICHIRO KIMURA NAOKI MORI

High mobility group box 1 (HMGB1) functions as a chromatin-associated nuclear protein and an extracellular signaling molecule. The concentration of HMGB1 protein and the expression of HMGB1 mRNA were analyzed by ELISA and polymerase chain reaction (PCR), respectively. The present study reports high plasma HMGB1 levels in patients with adult T-cell leukemia [ATL; which is caused by infection wit...

Journal: :Journal of the National Cancer Institute 2001
S Hanabuchi T Ohashi Y Koya H Kato A Hasegawa F Takemura T Masuda M Kannagi

BACKGROUND Human T-cell leukemia virus type I (HTLV-I) is etiologically linked to adult T-cell leukemia (ATL). The disease has a high mortality rate and is resistant to chemotherapy; therefore, immunologic approaches to treatment could be of interest. We have previously shown that athymic rats inoculated with a syngeneic (i.e., with the same genetic background) HTLV-I-infected T-cell line (FPM1...

2010
Nishant Tageja Mobayed Mohammad Gail Bentley Carter Bishop

Adult T-cell Leukemia/Lymphoma (ATL) is rarely seen in the U.S. and Europe, usually limited to African Americans from the southeastern U.S. and immigrants from HTLV-1 endemic areas. Reaching an accurate and timely diagnosis of ATL in such nonendemic areas can be challenging, owing to limited exposure, diverse manifestations, and varying cell morphology. We present a case of chronic adult T-cell...

Journal: :Antiviral therapy 2011
Natsumi Araya Katsunori Takahashi Tomoo Sato Tatsufumi Nakamura Chika Sawa Daisuke Hasegawa Hitoshi Ando Satoko Aratani Naoko Yagishita Ryoji Fujii Hiroshi Oka Kusuki Nishioka Toshihiro Nakajima Naoki Mori Yoshihisa Yamano

BACKGROUND Human T-lymphotropic virus type-1 (HTLV-1) is a human retrovirus that causes HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukaemia (ATL). A higher viral load in individuals with HTLV-1 infection increases their risk of developing HAM/TSP and ATL. Moreover, the high proviral load is associated with the clinical progression of HAM/TSP. Reduction...

Journal: :Blood 2008
Jing Chen Mike Petrus Bonita R Bryant Vinh Phuc Nguyen Mindy Stamer Carolyn K Goldman Richard Bamford John C Morris John E Janik Thomas A Waldmann

The etiologic agent of adult T-cell leukemia (ATL) is human T cell lymphotropic virus type I (HTLV-I). The HTLV-I protein Tax alters gene expression, including those of cytokines and their receptors, which plays an important role in early stages of ATL. Here we demonstrate that expression of interleukin-9 (IL-9) is activated by Tax via an NF-kappaB motif in its proximal promoter, whereas IL-9 r...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید