نتایج جستجو برای: atl granzyme htlv

تعداد نتایج: 10406  

Journal: :The Journal of clinical investigation 1988
H Umadome T Uchiyama T Hori S Tamori T Motoi K Araki H Uchino

Human T cell leukemia/lymphoma (T-lymphotropic) virus type I (HTLV-I) infection has been considered to be closely associated with the leukemogenesis of adult T cell leukemia (ATL), in which interleukin 2 (IL-2) receptors are abnormally expressed. In this study, however, Southern blot analysis revealed no gross rearrangement or obvious amplification of the IL-2 receptor gene in ATL leukemic cell...

Journal: :Blood 1989
Y C Chen C H Wang I J Su C Y Hu M J Chou T H Lee D T Lin T Y Chung C H Liu C S Yang

Among 354 adult patients with either hematological malignancy or aplastic anemia, eight were positive for anti-HTLV-I antibodies; six of eight had received multiple transfusions. There was an approximately 3.5-fold increase (P less than .001) of HTLV-I seropositivity in the patients with hematologic disease (8 of 354, 2.23%) compared to the healthy adults older than 20 years (34 of 5252, .65%)....

Journal: :Blood 2010
Masako Iwanaga Toshiki Watanabe Atae Utsunomiya Akihiko Okayama Kaoru Uchimaru Ki-Ryang Koh Masao Ogata Hiroshi Kikuchi Yasuko Sagara Kimiharu Uozumi Manabu Mochizuki Kunihiro Tsukasaki Yoshio Saburi Masaomi Yamamura Junji Tanaka Yukiyoshi Moriuchi Shigeo Hino Shimeru Kamihira Kazunari Yamaguchi

Definitive risk factors for the development of adult T-cell leukemia (ATL) among asymptomatic human T-cell leukemia virus type I (HTLV-1) carriers remain unclear. Recently, HTLV-1 proviral loads have been evaluated as important predictors of ATL, but a few small prospective studies have been conducted. We prospectively evaluated 1218 asymptomatic HTLV-1 carriers (426 males and 792 females) who ...

Ali Shoeibi, Amir Moghaddam Ahmadi Mohammdmahdi Etemadi Mona Amini Reza Boostani,

    Human T-cell lymphotropic virus (HTLV) types 1 and 2 belong to the Oncorna group of retroviridae, a large family of viruses, grouped initially by pathogenic features, but later revised on the basis of genome structure and nucleotide sequence. HTLV-I was the first discovered human retrovirus to be associated with a malignancy in 1980. The malignancy, first described by Uchiyama and co-worker...

Journal: :Blood 2002
Naoki Mori Hiroshi Sato Toshihisa Hayashibara Masachika Senba Tomayoshi Hayashi Yasuaki Yamada Shimeru Kamihira Shuichi Ikeda Yoshihiro Yamasaki Shigeru Morikawa Masao Tomonaga Romas Geleziunas Naoki Yamamoto

Human T-cell leukemia virus type I (HTLV-I) is the etiologic agent of adult T-cell leukemia (ATL) and of tropical spastic paraparesis/HTLV-I-associated myelopathy. Infiltration of various tissues by circulating leukemic cells is a characteristic of ATL. Matrix metalloproteinases (MMPs), which mediate the degradation of the basement membrane and extracellular matrix, play an important role in me...

1999
Naoki Mori Masahiro Fujii Shuichi Ikeda Yasuaki Yamada Masao Tomonaga Dean W. Ballard Naoki Yamamoto

Human T-cell leukemia virus type I (HTLV-I) is an etiologic agent of adult T-cell leukemia (ATL). The viral protein Tax induces the activation and nuclear translocalization of transcription factor NF-kB, which is proposed to play a crucial role in the transformation of T cells by HTLV-I. However, the HTLV-I genes including Tax are not expressed significantly in primary leukemic cells from ATL p...

2002
Naoki Mori Yasuaki Yamada Shuichi Ikeda Yoshihiro Yamasaki Kunihiro Tsukasaki Yuetsu Tanaka Masao Tomonaga Naoki Yamamoto Masahiro Fujii

Human T-cell leukemia virus type I (HTLV-I) is the causative agent of an aggressive form of leukemia designated adult T-cell leukemia (ATL). We have previously demonstrated that all T-cell lines infected with HTLV-I and primary leukemic cells from ATL patients display constitutively high activity of transcription factor NFB. In this study we showed that Bay 11-7082, an inhibitor of NFB, induced...

Journal: :Blood 2002
Naoki Mori Yasuaki Yamada Shuichi Ikeda Yoshihiro Yamasaki Kunihiro Tsukasaki Yuetsu Tanaka Masao Tomonaga Naoki Yamamoto Masahiro Fujii

Human T-cell leukemia virus type I (HTLV-I) is the causative agent of an aggressive form of leukemia designated adult T-cell leukemia (ATL). We have previously demonstrated that all T-cell lines infected with HTLV-I and primary leukemic cells from ATL patients display constitutively high activity of transcription factor NF-kappaB. In this study we showed that Bay 11-7082, an inhibitor of NF-kap...

Journal: :Blood 1993
S Ikeda S Momita K Kinoshita S Kamihira Y Moriuchi K Tsukasaki M Ito T Kanda R Moriuchi T Nakamura

To characterize the prodromal phase of adult T-cell leukemia (ATL), a prospective follow-up study was conducted on 50 carriers in a putative pre-ATL state. This state was defined by the presence of molecularly-detectable monoclonal proliferation of human T-lymphotropic virus type I (HTLV-I)-infected T lymphocytes, and the absence of clinical symptoms of leukemia. The median observation time was...

Journal: :Haematologica 2005
Mordechai Shtalrid Lev Shvidel Roman Korenfeld Adrian Duek Zvi Landau Alain Berrebi

Human T-lymphotropic virus type 1 (HTLV-1) was the first human oncovirus isolated by Gallo et al. in 1980 and established as an etiological agent for adult T-cell leukemia/ lymphoma (ATL). Although more than 15 million individuals are infected by HTLV-1 through the world, the spread of the virus is highly endemic. The HTLV-1 infection is prevailing in southwestern Japan, inter-tropical Africa, ...

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