نتایج جستجو برای: atl granzyme htlv

تعداد نتایج: 10406  

Journal: :Microbes and infection 2009
Ryo Takayanagi Takashi Ohashi Hisatoshi Shida

Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia (ATL). Some ATL cells express Foxp3, which is known as regulatory T cell (Treg cell) specific transcription factor. It is suggested that Treg cell like suppressive activity of Foxp3 expressing ATL cells is associated to ATL development and related immunodeficiency. To develop an HTLV-1 model system that ...

Journal: :Blood 2005
Keitarou Doi Xiaolin Wu Yuko Taniguchi Jun-ichirou Yasunaga Yorifumi Satou Akihiko Okayama Kisato Nosaka Masao Matsuoka

Human T-cell leukemia virus type I (HTLV-I) is a causative agent of neoplastic disease, adult T-cell leukemia (ATL). Although the encoding viral proteins play an important role in oncogenesis, the role of the HTLV-I proviral integration site remains unsolved. We determined the integration sites of HTLV-I proviruses in ATL cells and HTLV-I-infected cells in asymptomatic carriers. In carrier and ...

2017
Qingsong Huang Zhiguo Niu Jingxian Han Xihong Liu Zhuangwei Lv Huanhuan Li Lixiang Yuan Xiangping Li Shuming Sun Hui Wang Xinxiang Huang

Human T cell leukemia virus type 1 (HTLV-1) is a complex retrovirus that causes adult T cell leukemia (ATL) in susceptible individuals. The HTLV-1-encoded oncoprotein Tax induces persistent activation of the nuclear factor-κB (NF-κB) pathway. Early growth response protein 1 (EGR1) is overexpressed in HTLV-1-infected T cell lines and ATL cells. Here, we showed that both Tax expression and HTLV-1...

2015
Zohreh Dalirsani Abbas Javadzade Bolouri Zahra Delavarian Salma Bidad Majid Sanatkhani Maryam Amirchaghmaghi

Human T-lymphotropic virus-1 (HTLV-1) can cause adult T-cell leukemia/ lymphoma (ATL/L), which is a rare and aggressive type of blood cancer. Herein, we report a case of ATL/L in a middle-aged man with unusual jaw presentations. The patient presented with mandibular, maxillary and palatal bony hard expansion, accompanied by generalized tooth mobility six months prior to admission to the Departm...

Journal: :Blood 2009
Marcia Bellon Yves Lepelletier Olivier Hermine Christophe Nicot

Human T-cell leukemia virus type-I (HTLV-I) is the etiologic agent of adult T-cell leukemia (ATL), an aggressive lymphoproliferative disease. MicroRNAs (miRNAs) are differentially expressed during hematopoiesis and lineage commitment of hematopoietic stem cell progenitors (HSCPs). Here, we report aberrant expression of hematopoietic-specific miR-223, miR-181a, miR-150, miR-142.3p, and miR-155 i...

2000
Atsushi Wake Yoshiya Tanaka Keisuke Nakatsuka Masahiro Misago Susumu Oda

Adutt T-cell leukemia (ATL) is a human T-cell leukemia virus type I (HTLV-l)-infected lymphoproliferative disorder that shows a characteristic nodular infiltration into various tissues, hypercalcemia, and subsequent rapid increase of peripheral ATL cell number. ATL cells and HTLV-l-infected T-cell lines also make cluster formation rapidly after the nonstimulative culture. However, the mechanism...

2015
Marcelo Magalhães Pedro D. Oliveira Achiléa L. Bittencourt Lourdes Farre

BACKGROUND Adult T-cell leukemia/lymphoma (ATL) is a mature T-cell neoplasia etiologically linked to HTLV-1. Manifestations of ATL are diverse and different clinical types with different tissue involvement and aggressiveness have been described. The mechanisms that lead to the development of ATL clinical types have not yet been clarified. Considering that in ATL patients HTLV-1 infection genera...

Journal: :Journal of immunology 2013
Yotaro Tamai Atsuhiko Hasegawa Ayako Takamori Amane Sasada Ryuji Tanosaki Ilseung Choi Atae Utsunomiya Yasuhiro Maeda Yoshihisa Yamano Tetsuya Eto Ki-Ryang Koh Hirohisa Nakamae Youko Suehiro Koji Kato Shigeki Takemoto Jun Okamura Naokuni Uike Mari Kannagi

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for adult T cell leukemia/lymphoma (ATL) caused by human T cell leukemia virus type 1 (HTLV-1). We previously reported that Tax-specific CD8(+) cytotoxic T lymphocyte (CTL) contributed to graft-versus-ATL effects in ATL patients after allo-HSCT. However, the role of HTLV-1-specific CD4(+) T cells in the eff...

2010
Kuan-Teh Jeang

The mechanism of HTLV-1 transformation of cells to Adult T cell leukemia (ATL) remains not fully understood. Currently, the viral Tax oncoprotein is known to be required to initiate transformation. Emerging evidence suggests that Tax is not needed to maintain the transformed ATL phenotype. Recent studies have shown that HTLV-1 transformed cells show deregulated expression of cellular microRNAs ...

Journal: :Blood 2005
Hidenori Sasaki Ichiro Nishikata Toshiyuki Shiraga Ena Akamatsu Takeshi Fukami Tomonori Hidaka Yoko Kubuki Akihiko Okayama Kenji Hamada Hisafumi Okabe Yoshinori Murakami Hirohito Tsubouchi Kazuhiro Morishita

Adult T-cell leukemia (ATL) caused by human T-cell leukemia virus type 1 (HTLV-1) infection, occurs in 2% to 4% of the HTLV-1 carriers with a long latent period, suggesting that additional alterations participate in the development of ATL. To characterize and identify novel markers of ATL, we examined the expression profiles of more than 12 000 genes in 8 cases of acute-type ATL using microarra...

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