objective(s): iscomatrix vaccines have now been shown to induce strong antigen-specific cellular or humoral immune responses to a broad range of antigens of viral, bacterial, parasite or tumor. in the present study, we investigated the role of iscomatrix charge in induction of a th1 type of immune response and protection against leishmania major infection in balb/c mice.  materials and methods:...

background: leishmaniasis is important vector-borne parasitic disease worldwide, caused by the genus leishmania . the objective of the current study was to identify genetic polymorphism in l. major , one of the species causing cutaneous leishmaniasis (cl), isolated from southeastern iran, using permissively primed intergenic polymorphic-polymerase chain reaction (ppip-pcr) method. methods: over...

background: treatment of cutaneous leishmaniasis (cl) is being faced with serious difficulties in fars province, due to emerging of resistance against meglumine antimonite (glucantime®). in this context, determining some biomarkers for drug sensitivity monitoring seems to be highly essential. different studies have been carried out to decipher the genes might be involved in antimony resistant p...

conclusions allium hirtifolium and z. spina-christi extracts showed the most efficient activity in the inhibition of promastigote growth, but this was not total. the remaining plant extracts indicated ineffective or very weak efficiency on the leishmania promastigotes. there is a possibility of achieving better results by changing the extraction method; determining materials affecting promastig...

Objective(s)Cutaneous leishmaniasis is a common parasitic disease which is endemic in some parts of the world. In vitro and in vivo studies have shown azithromycin efficacy on some Leishmania species. Because of structural similarity between clarithromycin and azithromycin and efficacy of clarithromycin against intracellular organisms and due to the absence of previous studies in this respect, ...

objective: leishmaniasis is one of the significant causes of morbidity and mortality in several countries. it is an important problem in endemic areas such as iran. the goal in treatment of leishmaniasis is to reduce the disease period and leave no evidence of any remaining scars or lesions. a derivative of artemisinin is artemether. scientists believe that the strong action of artemether again...

cutaneous leishmaniasis (cl) is the most common parasitic disease transmitted by vectors in iran. cl is endemic in many urban and rural parts of iran and usually caused by two species of leishmania as l . major and l . tropica transmitted to humans from parasite reservoirs by the bite of female sandflies. we report a case of ocular leishmaniasis with eyelid involvement presentation. the patient...

recent scientific evidence indicates that distinct patterns of susceptibility in balb/c mice to leishmania major infection are attributable to the differential expansion of distinct cd4+ t-cell subsets and their cytokines production. production of the th1 cytokine ifn-g is associated with resistance, whereas production of the th2 cytokines il-4 and il-10 are associated with extreme susceptibili...

background: cutaneous leishmaniasis (cl) is endemic in many tropical and subtropical regions of the world. due to the prolonged duration of therapy, adverse effect and resistance to current drugs in the treatment of cl, the dis­covery of novel, efficient, and safe leishmanicidal drugs is required. the aims of the present study was to synthesis of new compounds based on the active compounds of 5...

background: the present study was conducted to investigate the optimized timing for macrophages induction and nitric oxide (no) production against invading leishmania parasite. methods: the present study examined the murine macrophage cell line, b10r, in three different states. in the first state, the cells were first infected with l. major and then treated with ifn-g and lps as stimulants. in ...