In the past decade in Morocco, there has been a reactivation of zoonotic cutaneous leishmaniasis (ZCL) foci with an unusual long outbreak episode. The aims of this review article were to update our knowledge of this disease in Morocco, to compare the situation with that prevailing in the other countries of the Maghreb region and to highlight factors that could be responsible for the current sit...

Since interleukin-6 (IL-6) may promote Th2 responses, we infected BALB IL-6-deficient (IL-6(-/-)) mice with Leishmania major. There was not a significant difference between the courses of infection (lesion size and parasite burden) in IL-6(-/-) and wild-type mice, but IL-6(-/-) mice expressed lower levels of Th2- and Th1-associated cytokines.

Acral lentiginous melanoma (ALM) is the most common type of cutaneous melanoma in Asians. The very early stage of ALM demonstrates only a proliferation of a few atypical melanocytes within the epidermis, and has been termed ALM in situ. A 74-year-old male patient presented with a pigmented lesion on the left great toe for 12 years, which had initially showed only a few scattered hyperplastic at...

background: protozoa related to trypanosome family including leishmania , synthesize enzymes to escape from drug therapy. one of them is ptr1 that its enzymatic activity is similar to dihydrofolate reductase (dhfr). dihydrofolate reductase - thymidylate synthase has a major role in dna synthesis, if it is inhibited, the result would be the death of parasite. since ptr1 activity is similar to dh...

background: considering the prevalence of leishmaniasis in iran and many side effects associated with pentavalent antimony compounds use in its treatment, this study was designed to evaluate the effect of artemisia sieberi essence on the experimental ulcers of cutaneous leishmaniasis on balb/c mice. methods: this experimental research was performed to determine the effect of various concentrati...

objective(s) annual incidence of cutaneous leishmaniasis is increasingly growing and development of the alternative drugs against it is a major concern. artemisia genus is a traditional medicinal plant in iran. the aim of this study was to examine the leishmanicidal activity of various iranian artemisia species extracts. materials and methods different extracts were gathered from eleven iranian...

background: in leishmaniasis, some drugs prescribed for treatment have toxic ef-fects and there are reports about drug resistance in some countries. due to this fact, using herbal drugs such as artemisinin with good efficacy and low toxic effect might be suitable. methods: we evaluated the apoptotic effect of artemisinin on leishmania major in vitro and the antileishmanial activities of artemis...

background: the objectives of our research were to search for leishmania species in rodents in fars province, south of iran, and to compare molecular with conventional methods for detecting these para-sites. methods: rodents were captured using live traps and screened for leishmania species using molecular and conventional methods, including the taking of smears from each ear. nested pcr was em...

leishmaniasis is caused by parasitic protozoa of the genus leishmania. cutaneous leishmaniasis (cl) is a complex disease with wide spectrum of clinical manifestations. in order to identify leishmania species causing cl in isfahan by a definite molecular technique (pcr method), this study was undertaken over 2010- 2011. 124 patients with suspicious lesion of leishmaniasis and positive direct sme...