background and objectives: several natural compounds have been identified for the treatment ofleishmaniasis. due to a few safe drugs and the side effects caused by available chemotherapy, some new drugs for treatment of leishmaniasis are requested.  the genus pulicaria (asteraceae) is represented in the flora of iran by five species. phytochemical studies on pulicaria species have revealed some...

this experimental study was conducted to assess of effectiveness of two nanogold concentrations against cutaneous leishmaniasis (cl) caused by iranian strain of leishmania major in balb/c mice model. cutaneous lesions were experimentally induced by inoculation with iranian leishmania major promastigotes (mrho/ir/75/er) in 61 balb/c mice. the infected mice were enrolled to four groups: intervent...

background : leishmaniasis is an endemic disease in 88 countries. reports on leishmania drug resistance are growing in number. the mechanism of unresponsiveness against glucantime in iranian cutaneous leishmaniasis has not yet been characterized. to begin the first step in finding an anti- leishmania chemotherapy, we prepared recombinant l. major ptr1 enzyme and characterized its activity by en...

background : leishmaniasis is an important public health disease in many developing countries as well in iran. the main objective of this study was to investigate on leishmania infection of wild caught sand flies in an endemic focus of disease in esfarayen district, north east of iran. methods : sand flies were collected by sticky papers and mounted in a drop of puri’s medium for species identi...

background: cutaneous leishmaniasis due to leishmania major has become a hot topic in iran. the objective of this study was to determine some ecological aspects of sand flies in the study area. methods: sand flies were collected biweekly from indoors and outdoors fixed places in the selected villages, using 30 sticky paper traps from the beginning to the end of the active season of 2006 in kerm...

background and objectives: current chemotherapies of cutaneous leihmaniasis have faced to some problems and limitations; development of new leishmanicidal drugs from different sources like herbal plants, are crucially important. the objective of the present study was evaluation of in vitro activity of alkanna frigida extracts in comparison with glucantime against leishmania major . materials an...

reports from the health center of kerman province, southern iran showed an increasing of cutaneous leishmaniasis cases in orzuieh rural district, southwest of the province in 2003. the report encouraged the team to carry out an epidemi ological survey in the district during 2003-2004. the objectives were to determine the ecology of sand flies, potential reser voir hosts and human infection. a t...

background cutaneous leishmaniasis with zoonotic and anthroponotic forms is an endemic disease and a health problem in our country. identification of parasite species and the type of disease is very important for treatment of disease as well as planning the control program. this study was carried out to identify the parasite species causing cutaneous leishmaniasis by nested pcr in poledokhtar d...