background: the purpose of this study was to evaluate antileishmanial effects of asa via no pathway in leishmania major infected balb/c mice. moreover, toxicity and pathological consequences of asa administration were investigated. methods: balb/c mice were infected with l. major and asa was inoculated orally after lesion appearance for its ability to modulate no and to modify leishmania infect...

various adjuvants in combination with different antigens have been utilized as a vaccine candidate against leishmaniasis. however, the search for ideal adjuvants is still pursued due to the inefficiencies of current compounds. in the present study, the effect of imiquimod, as an adjuvant, is studied with soluble leishmania antigens (sla) in balb/c mice. four groups of mice were immunized with s...

Thailand is considered as a non-endemic area for leishmaniasis. We report the first case of visceral leishmaniasis caused by Leishmania infantum in a Thai man living in Bangkok.

background: leishmania major lmsti1 is a conserved protein among different species of leishmania, and expressed in both amastigote and promastigote forms of l. major life cycle. it has previously been expressed in bacterial systems. m aterials and methods: to express lmsti1 in the methylotrophic yeast         pichia pastoris ( p. pastoris ), the shuttle vector ppicza containing gene lmsti1 was ...

abstract        background and objective: leishmania major is a flagellate protozoan parasite causing cutaneous leishmaniasis. although pentavalent antimony compounds are the first-line drugs for leishmaniasis, their application is often accompanied by numerous limitations and side effects. therefore, it is necessary to seek drugs of herbal origin that have fast-acting benefits and few side eff...

background: zoonotic cutaneous leishmaniasis (zcl) due to leishmania major is increasing in many parts of iran. this disease originally is a disease found in gerbils. leishmania parasites are transmitted by sandflies that live and breed in gerbil burrows. nested pcr amplified leishmania its1-5.8s rrna gene in both main reservoir host “rhombomys opimus” and in the “phlebotomus papatasi” main vec...

A series of eight substituted bis-2-hydroxy-1,4-naphthoquinone derivatives was synthesized through lawsone condensation with various aromatic and aliphatic aldehydes under mild acidic conditions. The title compounds were evaluated for antileishmanial activity in vitro against Leishmania amazonensis and Leishmania braziliensis promastigotes; six compounds showed good activity without significant...

a Zentrum für Molekulare Biologie, Im Neuenheimer Feld 282, Postfach 106249, D-6900 Heidelberg 1, Federal Republic of Germany b Department of Biological Chemistry and Molecular Pharmacology, Har6ard Medical School, 250 Longwood A6e., Boston, MA 02115, USA c Department of Molecular Microbiology, 760 McDonnell Science Building, Box 8230, Washington Uni6ersity School of Medicine, 660 South Euclid ...