Objective: Autophagy is necessary for the progression of psoriasis. This study aimed to recognize possible autophagy-related genes in psoriasis via bioinformatics present a better standard clinical treatment and management Methods: The GEO dataset was utilized derive mRNA expression profile database GSE78097. R software find autophagy-associated that may be expressed Then, Protein-protein inter...

Objective(s): Abnormal lung cell death including autophagy and apoptosis is the central feature in acute lung injury (ALI). To identify the cellular mechanisms and the chronology by which different types of lung cell death are activated during lipopolysaccharide (LPS)-induced ALI, we decided to evaluate autophagy (by LC3-II and autophagosome) and apoptosis (by caspase-3) at different time point...

Abstract Edwardsiella piscicida is an intracellular pathogenic bacterium accounting for significant losses in farmed fish. Currently, cellular and molecular mechanisms underlying E. piscicida–host cross-talk remain obscure. In this study, we revealed that could increase microtubule-associated protein L chain 3 (LC3) puncta grass carp (Ctenopharyngodon idella) monocytes/macrophages a cell line, ...

Abstract Autophagy plays an active anti-viral role in plants. Increasing evidence suggests that viruses can inhibit or manipulate autophagy, thereby winning the arms race between plants and viruses. Here, we demonstrate overexpression of m 6 A writer from Solanum lycopersicum , SlHAKAI, could negatively regulate pepino mosaic virus (PepMV) infection, viral RNA protein accumulations by affecting...

Trehalose, as a natural disaccharide, is known as an autophagy inducer. The neuroprotectiveeffects of trehalose in the rat model of Parkinson′s disease were the aim of the present study.Parkinson′s disease model was induced by injecting 6-hydroxydopamine (6-OHDA) in thestriatum of male Wistar rats. Apomorphine-induced behavior and substantia nigra neuronalcounts were app...

Abstract Autophagy enables the maintenance of nutrient recycling and metabolic homeostasis through a multistep lysosomal degradation pathway, it has been demonstrated that autophagy can act as tumor suppressor or promoter, depending on microenvironment (TME). The dual role in tumorigenesis results two opposing therapeutic strategies, namely, inhibition versus promotion. However, due to protecti...

OBJECTIVE Autophagy, an evolutionarily conserved process for the bulk degradation of cytoplasmic components, serves as a cell survival mechanism. The purpose of this study was to elucidate the role of autophagy in human chondrocytes and pathophysiology of osteoarthritis (OA). METHODS Autophagy in articular cartilage and primary chondrocytes was assessed using antibodies for the autophagy mark...

Autophagy is a protein and organelle degradation pathway that is involved in diverse diseases, including cancer. Recent evidence suggests that autophagy is a cell survival mechanism in tumor cells and that its inhibition, especially in combination with other therapy, could be beneficial but it remains unclear if all cancer cells behave the same way when autophagy is inhibited. We inhibited auto...

Autophagy, a process of bulk protein degradation and organelle turnover, is induced under starvation conditions in yeast and plays an important role in developmental processes and human diseases. Autophagy is a nonapoptotic form of programmed cell death. Disturbances in autophagy and programmed cell death may lead to cancer and several degenerative diseases in humans. During the routine ultrast...