Time-related changes in the incidences of spontaneous neoplasms in adrenals (medulla), mamma, liver, pituitary, and (endocrine) pancreas were assessed statistically in Wistar, Sprague-Dawley, and F344 rats employed by BASF, Germany and major European contract research organizations over the last 20 years. Negative trends (7 of 80 cases) were observed for pituitary pars distalis adenomas in Spra...

3772 | CrystEngComm, 2015, 17, 3772–3776 This journal is © The R a University of Konstanz, Physical Chemistry, Universitätsstraße 10, D-78457 Konstanz, Germany. E-mail: [email protected] Material Physics, BASF SE, GMC/O – G201, 67056 Ludwigshafen, Germany. E-mail: [email protected] c Reactive Systems and Inorganic Nanomaterials Research, BASF SE, GMV/N – J550, 67056 Lud...

The European Union legislation considers nongenotoxic substances that only cause liver tumors in certain sensitive strains of mice as raising no concern for man. The EU legislation, however, also clearly stipulates that cases where the only available tumor data are the occurrence of neoplasms at sites and in strains where they are well known to occur spontaneously with a high incidence are rele...