UNLABELLED BACKGROUND Inspired by the unprecedented historical success of cisplatin, one of the most important research directions in bioinorganic and medicinal chemistry is dedicated to the development of new anticancer compounds with the potential to surpass it in antitumor activity, while having lower unwanted side-effects. Therefore, a series of copper(II) mixed-ligand complexes of the t...

Fluorescent or biotin labelling of an oligonucleotide at it's 5'-end usually involves two steps. First, a N-protected aminoalkyl phosphoramidite derivative (as for instance Aminolink 2 from Applied Biosystems) is added to the 5'-end of an oligonucleotide during automated DNA synthesis. After removal of all protecting groups the NHS ester of an appropriate fluorescent dye or biotin is coupled to...

The reduction of gaseous oxygen on carbon-supported plat inum electrodes has been studied at 150~ with polarization and potential decay measurements. The electrolyte was either 100 weight percent phosphoric acid or that acid with a fluorinated additive, potassium perfluorohexanesulfonate (C6FI3SO3K). The pseudo-Tafel curves of the overpotential vs. log (iiL/(iL -i)) show a two-slope behavior, p...

We study electron and hole injection in MoO3 charge generation layers CGLs commonly used for establishing balanced injection in multilayer stacked organic light-emitting diodes SOLEDs . A compound CGL consisting of 100-Å-thick MoO3 and Li-doped 4,7-diphenyl-1,10-phenanthroline in a 1:1 molar ratio is demonstrated to have a high electron generation efficiency. Charge injection from the compound ...

Delta opioid peptide [D-Ala,D-leu]enkephalin (DADLE) can prolong organ preservation and increases myocardial tolerance to ischemia. Our study examined the protective property of DADLE against methamphetamine(METH) induced dopaminergic terminal damage in the central nervous system. Because the neurotoxicity of METH involves reactive oxygen species, we also examined if DADLE might be an antioxida...

Non transferrin bound iron comprises the forms of plasma iron which are not bound to its traditional transporter plasma protein transferrin. Such forms of iron have been suggested to be toxic due to its redox activity through Haiber weiss and Fenton chemistry. Non transferrin bound iron has been widely studied in patients suffering from iron overload conditions like hemochromatosis and thalasse...