A new chromophore, 2-(4-nitrophenyl)-1H-indole (NPI), was synthesized as a potential photolabile protecting group. Caged benzoic acids featuring the NPI chromophore were model compounds. Benzoic acid released in moderate yields (~ 40–60%) upon photolysis of caged without any additional chemical reagents. Interestingly, an aldehyde, 1-(5-(1-formyl-1H-indol-2-yl)-2-nitrophenyl)ethyl benzoate, iso...

1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]-piperazine (Lu AA21004) is a novel antidepressant that is currently in late-stage clinical development for major depressive disorder. In the present study, the metabolism of Lu AA21004 was investigated using human liver microsomes (HLM), human liver S9 fraction, and recombinant enzymes. Lu AA21004 was found in vitro to be oxidized to a 4-hydroxy-phenyl...

The development of one-pot imine formation and asymmetric Pictet-Spengler reactions cocatalyzed by a chiral thiourea and benzoic acid is described. Optically active tetrahydro-beta-carbolines, ubiquitous structural motifs in biologically active natural products, are obtained in high ee directly from tryptamine and aldehyde precursors.

In this research the polymer which contains aldehyde group [H1] has been prepared by oxidation [H] using oxidizing agent (Dess Martin Periodinane), dialyzed ethanol, Schiff bases[H2,H5andH8] compounds have through reaction of compound with appropriate amines, [H3] hydroquinazolin ring [H2] 2-amino benzoic acid.[H4]which cyclization phthalic anhydride. [H6,H7]were [H5] acid and anhydriede. React...

Apple replant disease (ARD) is an important problem in the production of apple. The phenolic acid is one of the causes of ARD. How phenolic acid affects the ARD was not well known. In this study, we analyzed the type, concentration and annual dynamic variation of phenolic acid in soil from three replanted apple orchards using an accelerated solvent extraction system with high performance liquid...

Cinnamyl alcohol dehydrogenases (CAD; 1.1.1.195) catalyse the reversible conversion of p-hydroxycinnamaldehydes to their corresponding alcohols, leading to the biosynthesis of lignin in plants. Outside of plants their role is less defined. The gene for cinnamyl alcohol dehydrogenase from Helicobacter pylori (HpCAD) was cloned in Escherichia coli and the recombinant enzyme characterized for subs...

Komak bean (Lablab purpureus (L.) Sweet) belongs to the family Fabaceae and subfamily Papilionidae. Komam is cultivated by people for consumption as an additional food source. Informationabout active compound content of komak needed a reference in utilization komak. This research aims determine compounds contained seed Sweet). study used GC-MS analysis components seed. Based on result, Beak Bon...

The Baeyer–Villiger oxidation (BVO) of ketone and aldehyde can produce ester formate, which both have wide applications in many areas. In this work, a series Sn-containing silicates were prepared through the sol-gel process by using structure-directing crystallizing agents post-synthetic coordinated modification binaphthol. Characterizations revealed that loading (L)-sodium lactate as agent dec...

Vanadium substituted mesoporous AlPO have been synthesised using structure-directing surfactant under hydrothermal synthesis conditions. The presence of V in the framework of AlPO has been established by ESR, XPS, UV–vis DRS and ICP-AES measurements. This system is capable of promoting the oxidation of toluene to aldehyde and benzoic acid when the oxidising agent is 70% tert-butyl hydroperoxide...