نتایج جستجو برای: biginelli like reaction

تعداد نتایج: 1041717  

2012
Vivekanand B. Jadhav Harish V. Holla Sunil U. Tekale Rajendra P. Pawar

The Biginelli reaction, which is a three-component reaction for the synthesis of dihydropyrimidinone and corresponding dihydropyrimidinethiones (DHPMs) is known for more than a century. A large number researchers have shown consistent attention towards the study of Biginelli reaction, leading towards structurally diversified molecular libraries of DHPMs and it’s analogues, having significant bi...

Journal: :iranian journal of pharmaceutical research 0
ghodsi mohammadi sakineh faramarzi alzahra university shima asadi alzahra university massoud amanlou tehran university

sulfonic acid functionalized sba-15 (sba-pr-so3h) with pore size 6 nm as an efficient heterogeneous nanoporous solid acid catalyst exhibited good catalytic activity in the biginelli-like reaction in the synthesis of spiroheterobicyclic rings with good yield and good recyclability. spiro-pyrimidinethiones/spiro-pyrimidinones-barbituric acid derivatives were synthesized in a simple and efficient ...

Journal: :Molecules 2009
Chen-Jiang Liu Ji-De Wang

A simple, efficient procedure for the one-pot Biginelli condensation reaction of aldehydes, beta-ketoesters and urea or thiourea employing copper(II) sulfamate as a novel catalyst is described. Compared to the classical Biginelli reaction conditions, the present method has the advantages of good yields, short reaction times and experimental simplicity.

Journal: :Molecules 2015
Yonghong Zhang Bin Wang Xiaomei Zhang Jianbin Huang Chenjiang Liu

We report here an efficient and green method for Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea catalyzed by Brønsted acidic ionic liquid [Btto][p-TSA] under solvent-free conditions. Compared to the classical Biginelli reaction conditions, the present method has the advantages of giving good yields, short reaction times, near room temperature conditions and the ...

2015
Ângelo de Fátima Taniris C. Braga Leonardo da S. Neto Bruna S. Terra Breno G.F. Oliveira Daniel L. da Silva Luzia V. Modolo

Since the disclosure of Biginelli reaction by the chemist Pietro Biginelli, functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) have emerged as prototypes for the design of compounds with a broad variety of biological activities. This mini-review describes over 100 Biginelli adducts demonstrated to be promising anticancer, inhibitors of calcium channel, anti-inflammatory, antimicrobi...

Journal: :Accounts of chemical research 2000
C O Kappe

In 1893, P. Biginelli reported the synthesis of functionalized 3, 4-dihydropyrimidin-2(1H)-ones (DHPMs) via three-component condensation reaction of an aromatic aldehyde, urea, and ethyl acetoacetate. In the past decade, this long-neglected multicomponent reaction has experienced a remarkable revival, mainly due to the interesting pharmacological properties associated with this dihydropyrimidin...

Journal: :The Journal of organic chemistry 1997
C. Oliver Kappe

The mechansim of the three-component Biginelli dihydropyrimidine synthesis was reinvestigated using (1)H and (13)C NMR spectroscopy. Condensation of benzaldehyde, ethyl acetoacetate, and urea (or N-methylurea) in CD(3)OH according to the procedure described by Biginelli produced the expected 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates. According to NMR measurements, ther...

Journal: :iranian chemical communication 0
asadollah farhadi petroleum university of technology of ahwaz mohammad ali ali takassi petroleum university of technology ahwaz lila hejazi petroleum university of technology ahwaz

the chemistry of 2-oxo-1,2,3,4-tetrahydropyrimidines began to develop toward the end of 1893 year, when the first representatives of this class compounds were reported by p. biginelli. despite prior reports of several really effective catalytic and non-catalytic approaches towards biginelli-type products, an overwhelming number of new catalysts for the biginelli reaction have been recently publ...

2012
Harshita Sachdeva Diksha Dwivedi

Various Biginelli compounds (dihydropyrimidinones) have been synthesized efficiently and in high yields under mild, solvent-free, and eco-friendly conditions in a one-pot reaction of 1,3-dicarbonyl compounds, aldehydes, and urea/thiourea/acetyl thiourea using lithium-acetate as a novel catalyst without the addition of any proton source. Comparative catalytic efficiency of lithium-acetate and po...

Journal: :Synfacts 2022

Key words (±)-saxitoxin - paralytic shellfish toxins Eschenmoser sulfide contraction Biginelli reaction Curtius rearrangement Meerwein's salt

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