SCOEL has already issued Summary Documents on both Lead and Lead Compounds (SCOEL/SUM 83) and Hexavalent Chromium Compounds (SCOEL/SUM 86), to which reference is made. On this basis, the present Summary Document on Lead Chromate is focussed on experimental data on the genotoxicity of lead chromate and on the issue of bioavailibility. Specific data on lead chromate published after the latest IAR...

SCOEL has already issued Summary Documents on both Lead and Lead Compounds (SCOEL/SUM 83) and Hexavalent Chromium Compounds (SCOEL/SUM 86), to which reference is made. On this basis, the present Summary Document on Lead Chromate is focussed on experimental data on the genotoxicity of lead chromate and on the issue of bioavailibility. Specific data on lead chromate published after the latest IAR...

We investigated bioavailability, as measured by the biota-sediment accumulation factor (BSAF), of reversibly sorbed and desorption-resistant phenanthrene to the deposit-feeding freshwater tubificid oligochaete Ilyodrilus templetoni. Desorption-resistant, phenanthrene-contaminated sediments were prepared by a sequential batch desorption method by washing with an isopropanol solution. The BSAFs a...

The drug making resreach has accentuated on extrusion technology for a long time. The advance of drug bioavailibility, bead manufacturing and granulation is assured by extrusion procedures. There are also diverse effects in resereches with respect to the use of process understanging as a tool in quality management. Many initiatives of FDA such as PAT and QBD are getting accepted. In this survey...

Experience has taught us that the rational clinical development of novel putative cancer chemopreventive agents needs to be based on robust preclinical information. Such information should relate to the mechanism of action, pharmacodynamics, and pharmacokinetics of the agent under study. Deficiencies in knowledge of any of these areas confound the understanding of the reasons for failure, when ...

Soils in the Lower Swansea Valley, (United Kingdom) contain elevated level of metals, enough to cause direct or indirect effects on human health. This study assesses severity soil pollution and bioavailability Cu other metals (Ni, Zn, Co, Pb Cr) soils with various distances from a Ni refinery. We compare concentrations operationally defined fractions (bioavailable, bound Fe/Mn oxide incorporate...

Trikatu, an Ayurvedic formulation of three dried powder spices, ginger, black pepper and pipali in equal proportion is widely used to promote digestion, assimilation and bioavailibility of food. It works synergistically, and hence, is more effective than an equal amount of any of its three ingredients taken separately. Five different brands and its three constituents were analyzed for 31 elemen...

OBJECTIVE To study the bioavailibility of nonheme iron from standard and test meals in Pakistani adults and to determine iron absorption using extrinsically tagged iron 59Fe. SUBJECTS AND METHODS Nonheme iron absorption was measured from standard and test meals in ten healthy individuals. Total calories, carbohydrates, proteins, fats, ascorbic acid, total iron, phytate and ascorbic acid conte...