Biofilms are microbial communities, embedded in a polymeric matrix, growing attached to a surface. Nearly all device-associated infections involve growth in the biofilm life style. Biofilm communities have characteristic architecture and distinct phenotypic properties. The most clinically important phenotype involves extraordinary resistance to antimicrobial therapy, making biofilm infections v...

conclusions coexistence of the blaoxa-51, blaoxa-23 and blaoxa-24/40 like genes, along with formation of strong biofilm, in mdr-ab strains particularly with indiscriminate use of imipenem, complicated treatment of the patients infected with these bacteria in the hospitals understudy. background emergence and spread of carbapenemase (blaoxa) genes in multidrug resistant acinetobacter baumannii (...

objective(s): pseudomonas aeruginosa is a nosocomial pathogen resistant to most antimicrobial treatments. furthermore, it persists in adverse environments thereby forming biofilms on various surfaces. researchers have therefore focused on antibiofilm strategies using nanoparticles due to their unique physicochemical properties. superparamagnetic iron oxide nanoparticles (sionps) have recently s...

Biofilm formations play an important role in Staphylococcus aureus pathogenesis and contribute to antibiotic treatment failures in biofilm-associated infections. The aim of this study was to evaluate the pharmacokinetic/pharmacodynamic (PK/PD) profiles of cefquinome against an experimental catheter-related biofilm model due to S. aureus, including three clinical isolates and one non-clinical is...

Back ground: S. aureus especially methicillin and multi drug resistant (MRSA MDRSA) has the tendency to form biofilm. Our aim was study in vitro biofilm-forming ability of isolates examine relationship between biofilm formation antibiotic resistance pattern. Methods: One hundred forty one clinical were isolated from wound pus tracheal aspirate samples. Biofilm these detected by Congo red (CRA) ...

Biofilm structural heterogeneity affects a broad range of microbially catalysed processes. Solute transport limitation and autoinhibitor production, two factors that contribute to heterogeneous biofilm development, were investigated using BacMIST, a computer simulation model. BacMIST combines a cellular automaton algorithm for biofilm growth with Brownian diffusion for solute transport. The sim...

The roles of toxin-antitoxin (TA) systems in bacteria have been debated. Here, the role of five TA systems in regard to biofilm development was investigated (listed as toxin/antitoxin: MazF/MazE, RelE/RelB, ChpB, YoeB/YefM, and YafQ/DinJ). Although these multiple TA systems were reported previously to not impact bacterial fitness, we found that deletion of the five TA systems decreased biofilm ...

Abstract Background Klebsiella pneumoniae is a common cause of nosocomial infections. Antibiotic resistance and ability to form biofilm, as two key virulence factors K. , are involved in the persistence The purpose this study was investigate correlation between antimicrobial biofilm formation capability among strains isolated from hospitalized patients Iran. Methods Over 10-month period, total ...

BACKGROUND AND PURPOSE Enterococcus faecium is a normal bowel commensal and lactic acid bacterium that is rarely found in the oral cavity. This study investigated whether a non-pathogenic and non-biofilm strain of E. faecium functioned as a probiotic strain toward biofilm formation by Streptococcus mutans, which is an etiological agent for dental caries. METHODS The effects of E. faecium on s...