Bisphenol A (BPA) is a monomer commonly used in the production of epoxy resins, plastic bottles and dental filling materials. Due to its chemical structure, BPA derivates show activity similar endocrine hormones. It can bind estrogen receptors cause neurological disturbances, even at low doses. Therefore, it important determine derivatives quickly sensitively concentrations. In this study, sing...

Bisphenol A can leach out from the plastic surfaces of food containers and has been detected in various matrices such as plasma, urine and groundwater. Bipshenol A is an endocrine disruptor, which can mimic the body’s own hormones such as estrogen and may lead to negative health effects. In this Application Note, we describe a method to quantify bisphenol A and a structurally similar analog bis...

Bisphenol A, an environmental oestrogenic chemical, was found to conjugate highly with glucuronic acid in male rat liver microsomes studied in vitro. In the various isoforms tested (1A1, 1A3, 1A5, 1A6, 1A7 and 2B1), glucuronidation of bisphenol A and of diethylstilboestrol, a synthetic crystalline compound possessing oestrogenic activity and known to be glucuronidated by liver microsomes, was c...

The effects of bisphenol A and nonylphenol on pubertal development in the intact juvenile/peripubertal male Sprague-Dawley rats was observed in this study from PND23-52/53. Two groups of rats were administered orally with either 100 mg/kg body weight of nonylphenol or bisphenol A. Another group of rats were administered orally with a mixture of 100 mg/kg body weight of nonylphenol and bisphenol...

Eye-pigmented eggs of landlocked salmon were exposed to waterborne [14C]-labeled bisphenol A at four temperatures (2, 6, 8, and 12 degrees C). Both in accumulation and depuration experiments, the eggs were exposed to a bisphenol A concentration of 1 microg/L for 196 h. In the depuration experiment, the exposed eggs were placed into clean water for 96 h. At each sampling time, the eggs were diss...

Exposure to environmental chemicals with estrogenic activity during the early stage of pregnancy can seriously affect embryonic development and the maintenance of pregnancy. To estimate the metabolism and pharmacodynamics of a xenoestrogen, bisphenol A, in a reproductive organ, the metabolite of bisphenol A was analyzed after incubating a rat uterine sac in buffer solutions containing the chemi...

Bisphenol is one of the commercial chemical compounds which finds application in manufacture phenol, polyesters, polycarbonates, epoxy resins, etc. A most commonly found bisphenol derivative, although there are various analogues such as S, B, C, E, AF, vary with their structures. Bisphenols majorly get into us by means food they packaging and beverage containers can be easily absorbed body. The...