aretaeus of cappadokia, lived in an era when cancer was already a disease, well known for its deadly outcome. inside his momentous treatise, composed of 8 books, he had outlined various types of cancer. he had understood cancer’s fatality and proposed some curative treatments. our manuscript composes the fragments related to cancer, in an effort to present aretaeus’ views on the matter.  he had...

To date, no other studies have examined the seasonal changes in circulating levels of various bile acids in the plasma of wild North American black bears, Ursus americanus. Using gas chromatography, bile acid concentrations were measured in plasma samples obtained during either early or late hibernation, and during summer active periods. Thus, specific compositional changes from individual anim...

Citation: Thomas J, Grey I (2016) From Black Bile to the Bipolar Spectrum: A Historical Review of the Bipolar Affective Disorder Concept. Arch Depress Anxiety 2(1): 010-015. DOI: 10.17352/2455-5460.000008 010 a common origin in excessive ‘black bile’ [7,8]. Furthermore, he connected the concepts, viewing them –mania and melancholia as different aspects of the same illness with mania conceptuali...

Pigment gallstones, which are much less frequent than cholesterol stones, are classified descriptively as "black" or "brown". They are composed mostly of calcium hydrogen bilirubinate, Ca(HUCB)(2), which is polymerized and oxidized in "black" stones but remains unpolymerized in "brown" stones. Black stones form in sterile gallbladder bile but brown stones form secondary to stasis and anaerobic ...

Freudenberg F, Leonard MR, Liu SA, Glickman JN, Carey MC. Pathophysiological preconditions promoting mixed “black” pigment plus cholesterol gallstones in a F508 mouse model of cystic fibrosis. Am J Physiol Gastrointest Liver Physiol 299: G205–G214, 2010. First published April 29, 2010; doi:10.1152/ajpgi.00341.2009.—Gallstones are frequent in patients with cystic fibrosis (CF). These stones are ...

Gallstones are frequent in patients with cystic fibrosis (CF). These stones are generally "black" pigment (i.e., Ca bilirubinate) with an appreciable cholesterol admixture. The pathophysiology and molecular mechanisms for this "mixed" gallstone in CF are unknown. Here we investigate in a CF mouse model with no overt liver or gallbladder disease whether pathophysiological changes in the physical...

Dear Editor, Estrogen deficiency in women is an important risk factor for serious disorders such as severe cardiovascular diseases (1). Several different conditions can lead to estrogen deficiency with premature ovarian failure (POF) being an important one (2, 3). POF includes the cessation of normal ovarian function before age 40, causing menopausal symptoms and general health problems. Althou...

BACKGROUND According to traditional Persian medicine (TPM) resources, the human digestive system includes four steps. In the first step, gastric digestion, the ingested food pours into the stomach and changes into the leachate called chylous due to the heat produced in the stomach. In the second step, hepatic digestion, the chylous enters in the liver through mesenteric vessels and transforms i...

The hydrolysis of esculin in the presence of bile has been utilized for many years for the identification of bacteria. It is especially useful in differentiating species of the genus Streptococcus. The procedure is a two-step one. First, the bacterium must grow in a particular concentration of bile, and second, it must hydrolyze esculin. The hydrolysis of esculin has traditionally been determin...