selective deficiency of immunoglobulin a (iga) is the most frequent primary hypogammaglobulinemia. as some iga-deficient patients have iga antibodies in their plasma which may cause anaphylactic reactions, blood centers usually maintain a list of iga-deficient blood donors to prepare compatible blood components. in this study we determined the incidence of selective iga deficiency (sigad) in no...

introduction: the main purpose of donor selection is not only the donor protection from blood donation complications but also the blood recipient not be expose to blood- transmitted diseases. this study aimed to determine the reason for exemption from donors among blood donor's who refer to ilam blood transfusion organization. materials and methods: this is a retrospective and descriptive ...

the hepatitis g virus (hgv) is a newly discovered rna virus, which is associated with acute or chronic hepatitis. a survey was conducted in thalassemic patients, intravenous drug users (ivdu) and blood donors aiming to investigate the prevalence of hepatitis g virus (hgv) infection in these groups in tehran. the presence of hgv rna in these populations was determined using reverse transcriptase...

introduction: human leukocyte antigen (hla) genes are the most polymorphic loci in the human genome. they predict the outcome of transplantation by detecting self from non-self antigens. the best use of hla typing is to find a hla-match donor for bmt candidate patients. evidence suggests that matching unrelated donors and recipients for hla-a, -b and -drb1 loci is a prediction for an improved o...

background and objectives: hepatitis e virus (hev) is a major public health concern in developing countries. hev transmission occurs primarily by the fecal-oral route. it has also been reported that blood donors are potentially able to cause transfusion-associated hepatitis e in endemic areas. this study aimed to determine the seroprevalence of hev infection among volunteer blood donors in cent...

background and objectives: tetanus and diphtheria are vaccine-preventable, infectious diseases with significant morbidity and mortality. immunization by the diphtheria and tetanus toxoid (dt) has been applied in iran for almost 50 years. however, there are very few data about the rate of immunity to these diseases in the adult population. the humoral immunity to tetanus and diphtheria among blo...

background: hepatitis b is the most common cause of acute viral hepatitis in the world. a small number of epidemiological studies, show the role of sucking insects in the transmission of hepatitis b as mechanical vector .in order to determine the prevalence of hbsag in patients with malaria and to compare with healthy blood donors, this study was conducted. methods: in this case-control study, ...

abstract mutations have been described in all of the four open reading frames of the hepatitis b virus (hbv), however, from a clinical perspective the surface escape mutant is the most troublesome. hepatitis b surface antigen (hbsag) variants may impair diagnosis, or allow the virus to escape vaccine-induced immunity or passive immunoglobulin therapy. hbv mutants with amino acid substitutions, ...

background: blood transfusion plays a great role in public health and the blood safety still has remained a main concern. hbv has been considered as one of the most prevalent blood borne infections. it is estimated that chronic hbv affects 350-400 million people worldwide. comprehensive knowledge about hbv has high importance in iran due to high number of blood dependent patients. material and ...

background: there are no data on the frequency and biochemical expression of the hemochromatosis associated mutations, c282y and h63d, in iranian adult population. this is the first study among iranians that may advocate a screening program. materials and methods: we investigated the frequency of the c282y/h63d hfe gene mutations in a group of 1029 randomly selected iranian blood donors as well...