The PDC (pyruvate dehydrogenase complex) is strongly inhibited by phosphorylation during starvation to conserve substrates for gluconeogenesis. The role of PDHK4 (pyruvate dehydrogenase kinase isoenzyme 4) in regulation of PDC by this mechanism was investigated with PDHK4-/- mice (homozygous PDHK4 knockout mice). Starvation lowers blood glucose more in mice lacking PDHK4 than in wild-type mice....

This paper presents a control algorithm for insulin delivery in Type I diabetic patients. The control algorithm utilize a robust H∞ controller to regulate the blood glucose level in diabetic patients. Diabetes mellitus is a family of chronic metabolic ailment in which body’s. In this study, Bergman’s minimal model has been used as a base model, to reformulate dynamics of insulin and glucose con...

abstract   background: the purpose of this study was to investigate the effects of aerobic training with and without drug modification on some blood metabolites and substrates in women with type 2 diabetes. methods: forty-nine women with type 2 diabetes were randomly divided into four groups as following: training-full drug, training-half drug, no training-full drug, and no training-half drug. ...

Activation of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients. It is therefore important to identify novel regulators of NST and cold-induced glucose uptake. Mammalian target of rapamycin complex 2 (mTORC2) mediates insulin-stim...

background: cardiopulmonary bypass (cpb) during coronary artery bypass grafting is thought to contribute significantly to increased blood glucose level and altered blood electrolytes balance during the operation. in this (cabg) study, blood electrolytes and glucose during cpb in insulin-dependent diabetic and non-diabetic patients were assessed with special emphasis on the trend of the changes....

background: hypoglycemia is one of the most common neonatal disorders, associated with severe complications. there has been a great deal of controversy regarding the definition and screening of hypoglycemia. therefore, in this study, we aimed to determine a cut-off value for blood glucose level in glucometer readings. methods: this cross-sectional study was conducted on 238 newborns at risk of ...

This study was designed to determine whether acute fructose or sucrose administration at different levels (0.05 g/kg, 0.1 g/kg or 0.4 g/kg body weight) might affect oral glucose tolerance test (OGTT) in normal and type 2 diabetic rats. In OGTT, there were no significant differences in glucose responses between acute fructose- and sucrose-administered groups. However, in normal rats, the AUCs of...