Update in Anaesthesia | www.worldanaesthesia.org CEREBRAl BlooD FloW The brain is unusual in that it is only able to withstand very short periods of lack of blood supply (ischaemia). This is because neurones produce energy (ATP) almost entirely by oxidative metabolism of substrates including glucose and ketone bodies, with very limited capacity for anaerobic metabolism. Without oxygen, energyde...

BACKGROUND Metabolic imaging with positron emission tomography (PET) can detect tissue viability in clinical infarct regions. With appropriate tracer kinetic models and serial PET imaging, regional myocardial blood flow and rates of metabolism can now be quantified in patients with recent myocardial infarctions. METHODS AND RESULTS Serial PET imaging with [13N]ammonia, [11C]acetate, and 18F-d...

tissue nutrient supply may be synchronized with endogenous physiological rhythms to optimize animal and human health. glucose tolerance and insulin sensitivity have endogenous rhythms that are not essentially dependent on food type and eating. human glucose tolerance declines as day comes into night. based on such evolutionary findings, large evening meals must be avoided to reduce risks of vis...

the role of parathyroid hormone on stature in major beta-thalassemic patients   gr. moshtaghi kashanian phd 1 , a. ahmadi md2, mm. hayat bakhsh md3   1- assistant professor, dept. of biochemistry, faculty of medicine, university of medical sciences, kerman, iran   2- professor of pediaterics, university of medical sciences, kerman, iran   3- assistant professor of internal medicine, faculty of ...

Activation of lipid peroxidation due to a disorder redox homeostasis in dogs with comorbidity babesiosis and dirofilariasis causes the involvement not only components hepatorenal system, but also cardiopulmonary system pathological process against background development intoxication hypoxic phenomena hepatocytes cardiomyocytes. As result conducted biochemical studies blood sick animals, it was ...

The brain comprises only 2% of total body weight; however, under normal conditions, it receives 15–20% of the cardiac output and accounts for 20% of total body oxygen consumption. Because energy reserves within the brain are negligible, adequate blood flow is essential for the provision of a continuous supply of energy-producing substrates and for the removal of the byproducts of cellular metab...

Cerebral blood flow is influenced and regulated by a number of factors, including arterial blood pressure, intracranial pressure, venous outflow, blood viscosity, PaCO2 and PaO2, collateral flow, vasoreactivity and the status of cerebral autoregulation. The regulation of vascular resistance lies mainly in the arterioles and precapillary segments (Auer and Loew, 1983). It is important to note th...

BackgroundResistin is reported as an antagonistic hormone of insulin and in the literature. Nowadays, importance of resistin is being more highlighted in the metabolism of mother and fetus during pregnancy. This study aimed to assess the level of resistin in the umbilical cord and blood sugar at birth and evaluate the association of resistin and neonatal birth weight.Materials and MethodsThis c...

During exercise regional cerebral blood flow (rCBF), as blood velocity in major cerebral arteries and also blood flow in the internal carotid artery increase, suggesting an increase in blood flow to a large part of the brain. Such an increase in CBF is independent of the concomitant increase in blood pressure but is modified by the alteration in arterial carbon dioxide tension (PaCO(2)). Also, ...

Polymorphonuclear leucocytes were isolated from cord-blood samples collected from healthy, term infants. Oxidative metabolism was assessed in these cells by hexose monophosphate shunt activity and chemiluminescence. Basal levels of oxidative metabolism were spontaneously increased in resting (nonphagocytic) cord-blood cells as compared to adult controls. As a response to phagocytosis, cord-bloo...