BACKGROUND Despite the widespread use of the Brief Psychiatric Rating Scale (BPRS), the clinical meaning of its total score and cut-off values used to define treatment response are unclear. AIMS To link the BPRS to Clinical Global Impression (CGI) ratings. METHOD Equipercentile linking of BPRS and CGI ratings from seven drug trials in acutely ill patients with schizophrenia (n=1979). RESU...

Introduction: Although the Brief Psychiatric Rating Scale (BPRS) is widely used for evaluating patients with schizophrenia, the meaning of the weights of the individual symptoms is ambiguous. The aims of the study were 1) to investigate whether the modification of relative weights of items of the BPRS is able to enhance its correlation with the Clinical Global Impression-Schizophrenia scale (CG...

Inhibition of the acoustic startle response by a smaller preliminary nonstartling stimulus is termed prepulse inhibition (PPI). Schizophrenia patients have impairments in PPI that may not fully normalize even when they are clinically stable on medication, particularly typical antipsychotics. There is evidence that more severe symptoms are associated with more severe PPI abnormalities, but the e...

The 24-item Brief Psychiatric Rating Scale (BPRS, version 4.0) enables the rater to measure psychopathology severity. Still, little is known about the BPRS's reliability and validity outside of the psychosis spectrum. The aim of this study was to examine the factorial structure and sensitivity to change of the BPRS in patients with unipolar depression. Two hundred and forty outpatients with uni...

Previous four- and five-factor solutions of the 18-item Brief Psychiatric Rating Scale (BPRS) suggested the possibility of an affective dimension in psychosis. A principal components analysis was used to analyze psychiatric symptom data rated on an expanded 24-item version of the BPRS. BPRS data were collected during a period of acute psychotic and affective illness with 114 young adult, recent...

Carcinogenesis is a complex multifactorial, multistage process, but the precise mechanisms are not well understood. In this study, we performed a genome-wide analysis of the copy number variation (CNV), breakpoint region (BPR) and fragile sites in 2,737 tumor samples from eight tumor entities and in 432 normal samples. CNV detection and BPR identification revealed that BPRs tended to accumulate...

The authors report the results of a confirmatory factor analysis of symptoms assessed with the Brief Psychiatric Rating Scale (BPRS) in a sample of 474 patients with schizophrenia, replicated in an independent sample of 327 patients. The most commonly used 5-factor solution for the BPRS fit the data poorly. Exploratory factor analyses performed on the first sample led to the specification of a ...

The dendritic processing in cerebellar Purkinje cells (PCs), which integrate synaptic inputs coming from hundreds of thousands granule cells and molecular layer interneurons, is still unclear. Here we have tested a leading hypothesis maintaining that the significant PC output code is represented by burst-pause responses (BPRs), by simulating PC responses in a biophysically detailed model that a...

This chapter addresses the second research question to explore the relationship characteristics of the clients and possible threat of discontinuity of bank-client relationships driven from exogenous factors such as external shocks and competitor moves and endogenous factors such as dissatisfaction. This exploratory study is a starting point to further discuss an explanatory analysis of the clie...

Signal detection in clinical trials relies on ratings reliability. We conducted a reliability analysis of site-independent rater scores derived from audio-digital recordings of site-based rater interviews of the structured Brief Psychiatric Rating Scale (BPRS) in a schizophrenia study. "Dual" ratings assessments were conducted as part of a quality assurance program in a 12-week, double-blind, p...