objective(s):estrogen (e2) has neuroprotective effects on blood-brain-barrier (bbb) after traumatic brain injury (tbi). in order to investigate the roles of estrogen receptors (ers) in these effects, er-α antagonist (mpp) and, er-β antagonist (phtpp), or non-selective estrogen receptors antagonist (ici 182780) were administered. materials and methods: ovariectomized rats were divided into 10 gr...

objective(s): brain edema is one of the most serious causes of death within the first few days after trauma brain injury (tbi). in this study we have investigated the role of shilajit on brain edema, blood-brain barrier (bbb) permeability, intracranial pressure (icp) and neurologic outcomes following brain trauma.   materials and methods: diffuse traumatic brain trauma was induced in rats by dr...

Background and Objective: The S100B protein has recently been considered as an important marker for predicting severe brain damage; however there has been very little evidence of increasing this marker in cerebral edema due to metabolic disorders such as diabetes ketoacidosis (DKA). This study was designed and performed to evaluate the prognostic role of S100B protein in predicting brain edema ...

pervious studies have shown that pentoxifylline (ptx) has beneficial effects in reduction of stroke and brain trauma injuries in experimental animals. however, there is very little and controversial information about the effect of ptx on brain edema in cerebral ischemia. therefore, the aim of this study was to determine the effects of different doses of ptx on brain edema and neurological motor...

background: central renin angiotensin system has an important role on the cerebral microcirculation and metabolism. our previous work showed that inhibition of angiotensin converting enzyme (ace) activity prior to induction of ischemia protected the brain from severe ischemia/reperfusion (i/r) injuries. this study evaluated the impacts of post-ischemic inhibition of ace, enalapril, on brain inf...