Introduction: Oxidative stress plays a crucial role in the impairment of synaptic plasticity following cerebral ischemia which ultimately results in memory dysfunction. Hence, application of antioxidant agents could be beneficial in the management of memory deficit after brain ischemia. Minocycline is a tetracycline antibiotic with antioxidant effect. The main objective of this work was to asse...

a b s t r a c t introduction: even today there is no effective drug therapy to prevent neuronal loss after brain stroke. in the present study we studied the effect of mitochondrial katp channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. materials & methods: rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with...

abstract ischemic brain edema is one of the most important complications of a stroke. this study aims to investigate the impact of pre-feeding of flax seed oil on blood-brain barrier in rat stroke model. in this experimental study animals were randomly divided into 3 groups of experiment, sham, and control. each testing group itself was consisted of 3 subgroups receiving doses of flaxseed oil w...

introduction: ischemia leads to loss of neurons by apoptosis in specific brain regions, especially in the hippocampus. the purpose of this study was investigating the effects of exercise preconditioning on expression of bax, bcl-2, and caspase-3 proteins in hippocampal ca1 neurons after induction of cerebral ischemia. methods: male rats weighing 260-300 g were randomly allocated into three grou...

Oxygen free radicals may be implicated in the pathogenesis of ischemia reperfusion damage. As the antioxidant effects of some species of Pistacia have been reported, the protective effects of Pistacia vera L. gum extract (0.1-0.5 g/kg) on oxidative damage following cerebral ischemia were studied in rats. Ischemia was induced using four-vessel occlusion model and evaluated using measurement of m...

Background: Probiotics are microorganisms that may influence brain function via altering brain neurochemistry. New research evidence suggests that probiotic bacteria might protect tissue damage through diminishing the production of free radicals and/or inflammatory cytokines. Therefore, this study was designed to evaluate the effects of probiotic bacteria on the prevention or reduction of brain...

Introduction: Nitric oxide seems to play a dual role in ischemia/reperfusion injury. Few studies have investigated whether it exacerbates or improves brain edema. In the present study, we inhibited the activity of nitric oxide synthase by L-NAME and evaluated the cerebral infarct volume, tissue swelling and brain edema, alongside the measurement of blood flow of the ischemic region. Methods...

A B S T R A C T Introduction: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied the effect of mitochondrial KATP channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. Materials & Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with...