نتایج جستجو برای: brca mutation

تعداد نتایج: 292614  

2016
Rong Bu Abdul K. Siraj Khadija A.S. Al‐Obaisi Shaham Beg Mohsen Al Hazmi Dahish Ajarim Asma Tulbah Fouad Al‐Dayel Khawla S. Al‐Kuraya

Ethnic differences of breast cancer genomics have prompted us to investigate the spectra of BRCA1 and BRCA2 mutations in different populations. The prevalence and effect of BRCA 1 and BRCA 2 mutations in Middle Eastern population is not fully explored. To characterize the prevalence of BRCA mutations in Middle Eastern breast cancer patients, BRCA mutation screening was performed in 818 unselect...

Journal: :Frontiers in genetics 2016
Nisreen Elsayegh Angelica M. Gutierrez Barrera Kimberly I. Muse Heather Lin Henry M. Kuerer Monica Helm Jennifer K. Litton Banu K. Arun

The authors retrospectively aimed to determine which of the following three scenarios, related to DCIS entry into BRCAPRO, predicted BRCA mutation status more accurately: (1) DCIS as an invasive breast cancer (IBC) entered using the actual age of diagnosis, (2) DCIS as IBC entered with 10 years added to the actual age of diagnosis, and (3) DCIS entered as no cancer. Of the 85 DCIS patients incl...

2013
Petra van der Groep Paul J. van Diest Yvonne H. C. M. Smolders Margreet G. E. M. Ausems Rob B. van der Luijt Fred H. Menko Joost Bart Elisabeth G. E. de Vries Elsken van der Wall

Recent studies have revealed that BRCA1 and BRCA2 germline mutation-related breast cancers show frequent overexpression of hypoxia inducible factor-1α (HIF-1α), the key regulator of the hypoxia response. However, the question remained whether hypoxia is a late stage bystander or a true carcinogenetic event in patients with hereditary predisposition. We therefore studied HIF-1α overexpression in...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2011
D J Gallagher J A Konner K M Bell-McGuinn J Bhatia P Sabbatini C A Aghajanian K Offit R R Barakat D R Spriggs N D Kauff

BACKGROUND Patients with BRCA-associated ovarian cancer (OC) have a survival advantage over those with sporadic OC. To further explore this, we examined the impact of prognostic factors on disease-free survival (DFS) and overall survival (OS) in patients with known BRCA mutation status. PATIENTS AND METHODS We reviewed stage III-IV OC patients treated at our institution between 1 December 199...

2017
Limor Helpman Omri Zidan Eitan Friedman Sarit Kalfon Tamar Perri Gilad Ben-Baruch Jacob Korach

OBJECTIVE The current study investigates disease patterns and outcomes in young Israeli epithelial ovarian cancer (EOC) patients and their association with BRCA mutation status. METHODS Consecutive EOC patients diagnosed at or below 50 years in a single institution between 1995-2011 were identified. All patients are referred for genetic counseling and testing for the predominant Jewish BRCA m...

Journal: :Cancer research 2001
D A Levine J Boyd

Our objectives were to test whether polymorphic variation in the (CAG)n repeat of the androgen receptor (AR) gene affects penetrance of germ-line BRCA mutations for ovarian cancer or age of diagnosis for ovarian cancer. Using a case-series study design, 179 consecutive Ashkenazi Jewish ovarian cancer patients were genotyped for AR repeat length and BRCA mutation status. There was no association...

2015
Koji Matsuo Katherine E. Tierney Diane M. Schneider Paulette Mhawech-Fauceglia Lynda D. Roman David M. Gershenson

•Tumor characteristics of 5 cases of ovarian tumor of low malignant potential (LMP) with BRCA mutation were examined.•Young age, BRCA1 mutation, and presence of invasive implants may be characteristics of BRCA carriers with ovarian LMP.

Journal: :The oncologist 2015
Zahi I Mitri Michelle Jackson Carolyn Garby Juhee Song Sharon H Giordano Gabriel N Hortobágyi Claire N Singletary S Shahrukh Hashmi Banu K Arun Jennifer K Litton

BACKGROUND BRCAPRO is a risk assessment model to estimate the risk of carrying a BRCA mutation. BRCA mutation carriers are at higher risk of developing breast, ovarian, pancreatic, and prostate cancer. BRCAPRO was developed for women and found to be superior to other risk assessment models. The present study evaluated the validity of BRCAPRO at predicting the risk of male patients carrying a BR...

2013
Uta Francke Cheri Dijamco Amy K. Kiefer Nicholas Eriksson Bianca Moiseff Joyce Y. Tung Joanna L. Mountain

Background. Inherited BRCA gene mutations convey a high risk for breast and ovarian cancer, but current guidelines limit BRCA mutation testing to women with early-onset cancer and relatives of mutation-positive cases. Benefits and risks of providing this information directly to consumers are unknown. Methods. To assess and quantify emotional and behavioral reactions of consumers to their 23andM...

2013
Manuel Machado Sofia Braga

Although the majority of breast cancers are sporadic, it is estimated that between 5% and 10% of cases are hereditary and mostly associated with BRCA 1 and BRCA 2 mutations. Women with BRCA 1 or BRCA 2 mutation present up to 95% increased risk of breast cancer and are advised to take preventive measures. Surveillance, chemoprevention and prophylactic surgery (mastectomy and oophorectomy) are ri...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید