The Bridelia ferruginea plant as anti-snake venom activity against the venom of a clinically important snake, Naja nigricollis was investigated. The Bridelia ferruginea leaves were dried and extracted with ethanol and bioactive compounds such as tannins alkaloids,saponnin,flavonoids,steroids,terpenoids were determined by standard method. The effect of the extract on some selected enzymes activi...

The root of Bridelia ferruginea is traditionally used as a treatment for type 2 diabetes. The objective of this study was to evaluate the effect of Bridelia ferruginea root bark ethyl acetate fractions (EA) on streptozotocin-induced diabetes and identify some chemical compounds. Ethyl acetate fraction (25 and 50 mg/kg/day) was administrated to streptozotocin-induced (60 mg/kg) diabetic mice for...

Bridelia ferruginea is a woody shrub that grows in the Savannah or rain forests of Africa and has traditionally been used to treat diabetes, arthritis and boils. Despite all these uses, extensive toxicological evaluation has not been carried out. The aim of the present investigation was to evaluate the sub-chronic toxicological effects of the stem bark aqueous extract of Bridelia ferruginea in ...

Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models. In this study the influence of B. ferruginea (BFE) on the production of PGE(2), nitrite, and proinflammatory cytokines from LPS-stimulated BV-2 microglia was investiga...

The aim of this study was to compare the mechanism of action of Bridelia ferruginea root bark hydro alcoholic extract to metformin and glibenclamide on diabetes and evaluate its safety in vitro. Materials and Methods: A single dose of B. ferruginea extract (250 mg/kg), metformin (100 mg) and glibenclamide (5 mg/kg) was administered to normal blood glucose level Wistar rats. Blood glucose and in...

the plant bridelia ferruginea benth (euphorbiaceae) has been known for its use in the management of oral thrush ethnomedicinally in various parts of africa, a practice which has been justified by results of certain scientific studies. the aim of this study was to develop an appropriate dosage formulation, a mouthwash and evaluate the antifungal potential of this dosage formulation against a maj...

The plant Bridelia ferruginea Benth (Euphorbiaceae) has been known for its use in the management of oral thrush ethnomedicinally in various parts of Africa, a practice which has been justified by results of certain scientific studies. The aim of this study was to develop an appropriate dosage formulation, a mouthwash and evaluate the antifungal potential of this dosage formulation against a maj...

Purpose: To characterize some preformulation properties of aqueous stem bark extract of Bridelia ferruginea Benth (Euphorbiaceae) (BF). Methods: The stem bark was extracted by maceration in hot distilled water. Two batches of granules containing the extract were prepared by wet granulation using maize starch, polyvinylpyrrolidone (PVP), Avicel PH-101, magnesium stearate, acacia and lactose as e...