BACKGROUND We estimated the nationwide burden of nosocomial S. aureus bloodstream infection (SA-BSI), a major cause of nosocomial infection, in South Korea. METHODS To evaluate the nationwide incidence of nosocomial SA-BSI, cases of SA-BSI were prospectively collected from 22 hospitals with over 500 beds over 4?months. Data on patient-days were obtained from a national health insurance databa...

Recent changes in healthcare systems have changed the epidemiologic paradigms in many infectious fields including bloodstream infection (BSI). We compared clinical characteristics of community-acquired (CA), hospital-acquired (HA), and healthcare-associated (HCA) BSI. We performed a prospective nationwide multicenter surveillance study from 9 university hospitals in Korea. Total 1,605 blood iso...

OBJECTIVES we assessed the incidence, risk factors and outcome of BSI over a 14-year period (2000-2013) in a Swedish county. METHODS retrospective cohort study on culture confirmed BSI among patients in the county of Östergötland, Sweden, with approximately 440,000 inhabitants. A BSI was defined as either community-onset BSI (CO-BSI) or hospital-acquired BSI (HA-BSI). RESULTS of a total of ...

BACKGROUND Having performed analytical validation studies, we are now assessing the clinical utility of the upgraded automated Bone Scan Index (BSI) in metastatic castration-resistant prostate cancer (mCRPC). In the present study, we retrospectively evaluated the discriminatory strength of the automated BSI in predicting overall survival (OS) in mCRPC patients being treated with enzalutamide. ...

BACKGROUND Bloodstream infections (BSI) have been traditionally classified as either community acquired (CA) or hospital acquired (HA) in origin. However, a third category of healthcare-associated (HCA) community onset disease has been increasingly recognized. The objective of this study was to compare and contrast characteristics of HCA-BSI with CA-BSI and HA-BSI. METHODS All first episodes ...

BACKGROUND Bloodstream infections (BSI) due to carbapenem-resistant (C-R) Klebsiella pneumoniae (Kp) are of global concern from both clinical and public health standpoints. This retrospective study aimed to describe C-R Kp BSI epidemiology in a large teaching hospital in northern Italy. METHODS Between 1 January 2007 and 31 December 2014, annual incidences both of C-R Kp BSI and of carbapenem...

BACKGROUND Bone Scan Index (BSI) expresses tumor burden in bone as a percentage of total skeletal mass, but its significance for metastatic breast cancer patients is unknown. We investigated whether baseline BSI is associated with skeletal-related events (SREs) or survival and identified the cut-off BSI score for predicting SREs in metastatic breast cancer patients. METHODS We retrospectively...

Results The study was performed on 47 ICUs and 6506 patients, 180 PN and 123 BSI cases. Agreement for PN was k= 0.99 (CI95 0.98;1.00). When PN cases were divided in clinically and microbiologically defined PN, kappa values were 0.90 (CI95 0.86;0.94) and 0.72 (CI95 0.63;0.82) respectively. Diagnosis of PN varied among countries: 4 countries predominantly surveyed microbiologically defined PN whe...

BACKGROUND/AIMS Procalcitonin (PCT) may prove to be a useful marker to exclude or predict bloodstream infection (BSI). However, the ability of PCT levels to differentiate BSI from non-BSI episodes has not been evaluated in nosocomial BSI. METHODS We retrospectively reviewed the medical records of patients ≥ 18 years of age with suspected BSI that developed more than 48 hours after admission. ...

Sedimentary biogenic silica (BSi) accumulation was used in conjunction with a hypothetical model of BSi accumulation to show that BSi is a sensitive proxy for low-level phosphorus enrichment in the Great Lakes. We hypothesize that historic nutrient-driven changes in diatom production altered silica biogeochemistry and induced biologically mediated silica depletion (BMSD) and that a record of th...