C23 is an abundant and multi-functional protein, which plays an important role in various biological processes, including ribosome biogenesis and maturation, cell cycle checkpoints and transcriptional regulation [1, 2]. However, the role of C23 in controlling tumorigenesis has not been well defined. Here we report that C23 is highly expressed in cancer cells and the elevated expression of C23 f...

The highly toxic organophosphorus (OP) nerve agent VX is characterized by a remarkable biological persistence which limits the effectiveness of standard treatment with atropine and oximes. Existing OP hydrolyzing enzymes show low activity against VX and hydrolyze preferentially the less toxic P(+)-VX enantiomer. Recently, a phosphotriesterase (PTE) mutant, C23, was engineered towards the hydrol...

Steroidal sapogenins bearing a good leaving group at C23 undergo a completely stereospecific rearrangement under a variety of conditions via a mechanism involving neighboring-group participation by the acetal oxygen atom in the departure of the nucleofuge from C23. The reactions of equatorial (23S)-23-bromo- or (23S)-23-tosyloxyspirostanes with either the alpha (25R) or beta (25S) oriented 25-m...

Among terrestrial orchids, and particularly among the subtribe Orchidinae, flies are underrepresented as pollinators. The European Neotinea ustulata, which developed specialized pollination by tachinid flies, is known to produce high relative concentrations of floral cuticular alkenes (Z)-11-tricosene (Z)-11-pentacosene (referred (Z)-11-C23/C25enes), seem be uncommon orchid flowers. If evolutio...

has extensive and well-developed Golgi apparatus. This is particularly important in the application of C23/11 as a fusion partner in human monoclonal antibody production. The electron micrograph studies also confirmed this excentric nucleation pattern. lrnmunohistochemical analysis of the paraproteins secreted by C23/11 showed that both K and 1 chains were present. Some reports have shown that ...

To determine whether red blood cell-mediated microinjection of antibodies can be used to study nuclear protein localization and function, we microinjected antibodies that have been shown to react specifically with nucleolar acidic phosphoprotein C23 into Walker 256 cells. The intracellular distribution of microinjected anti-C23 antibodies and preimmune immunoglobulins were determined by immunof...

Murraya koenigii (Curry leaf tree), from the Rutaceae family, is a medicinally important herb of Indian origin and now were widely distributed throughout southern Asia. The bark of Malayan Murraya koenigii was selected for phytochemical investigation. The isolation of chemical constituents from its hexane and dichloromethane extract was carried out by using different chromatographic techniques....