Our laboratory has reported (J. W. Freeman et al.. Cancer Res., 48: 1244-1251, 1988) a proliferation-associated M, 120,000 nucleolar anti gen (pi20), that was found in human tumors but was not detectable in most normal resting tissues and in benign tumors. To study further the function and the localization of this protein, we have investigated various methods of microinjecting p120 monoclonal a...

Our laboratory has reported (J. W. Freeman et al., Cancer Res., 48:1244-1251, 1988) a proliferation-associated Mr 120,000 nucleolar antigen (p120), that was found in human tumors but was not detectable in most normal resting tissues and in benign tumors. To study further the function and the localization of this protein, we have investigated various methods of microinjecting p120 monoclonal ant...

Viral infection imposes a major threat to human health. To develop new potent antiviral agents, Hederagenin (HE), known inhibitor of HIV-1 and HCV NS3/4A proteases, was used as starting material synthesize 4 types HE derivatives, HE-3,23-diacyl, HES-3,23-diacyl, HES-3-acyl, HES-3-oxo-23-acyl. We evaluated the in vitro inhibitory activities derivatives against proteases. (3 β,23)-Di- O-diglutary...

Amaranthus caudatus is a nutrient-rich Andean pseudocereal with wide genetic variability. Six productive varieties (Oscar Blanco, Pucara, Tomina, Cotahuasi, Barbechos, and Guindo Criollo) were compared by proximate, mineral, fatty acid composition. The proximal content showed certain singularities in the varieties. Barbechos Criollo stood out for their fat (9.50% 9.01%, respectively), while Tom...

Magnetism of fullerene C60 was studied by three methods the density functional theory (DFT) calculation, laboratory experiment and astronomical observation. DFT revealed that most stable spin state non-magnetic one Sz=0/2. This is contrary to our recent study on void induced graphene molecules C23 C53 be magnetic Sz=2/2. Two combined model suggested two up-spin at every carbon pentagon ring may...

the effect of business regulations on economic growth (a selection of developed and developing countries) mohammad-hossein hosseinzade bahreini assistant professor of economics,ferdowsi university of mashhad mohammad ali falahi associate professor of economics,ferdowsi university of mashhad fatemeh erfany jahanshahi m.sc. in economics abstract in this research, the relationship between business...

Total glucocerebrosides of the sea cucumber Cucumaria frondosa (CFC) have been isolated from the less polar lipid fraction of the chloroform-methanol extract using high speed counter-current chromatography (HSCCC) with a two-phase solvent system composed of petroleum ether-methanol-water (5:4:1, v/v). Three glucocerebroside molecular species (CFC-1, CFC-2 and CFC-3) were isolated from crude tot...

The P2X7 receptor (P2X7R) plays an important role in diverse conditions associated with tissue damage and inflammation, meaning that the human P2X7R (hP2X7R) is an attractive therapeutic target. The crystal structures of the zebrafish P2X4R in the closed and ATP-bound open states provide an unprecedented opportunity for structure-guided identification of new ligands. The present study performed...