The spirastrellolides are a novel family of structurally unprecedented marine macrolides which show promising anticancer properties due to their potent inhibition of protein phosphatase 2A. In the preceding paper, a modular strategy for the synthesis of spirastellolide A methyl ester which allowed for the initial stereochemical uncertainties was outlined, together with the synthesis of a series...

BACKGROUND Haloquadratum walsbyi commonly dominates the microbial flora of hypersaline waters. Its cells are extremely fragile squares requiring >14%(w/v) salt for growth, properties that should limit its dispersal and promote geographical isolation and divergence. To assess this, the genome sequences of two isolates recovered from sites at near maximum distance on Earth, were compared. PRINC...

By combining the partition method for enrichment of sulfatides without any chromatographic procedures and the preparation method of lysosulfatides, we succeeded in analyzing these sulfated glycosphingolipids from biological materials by matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) to reduce the complexity of mass fragmentation patterns within a...

Bu çalışmada, OECD ülkelerinde gelir dağılımı ve tüketim harcamaları incelenmektedir. çerçevede 34 ülkesini 1970-2021 dönemini kapsayan veri seti kullanılmıştır. Çalışmada hem içsellik problemini gidermek de uzun dönemde dinamik süreci daha iyi açıklayabilmek amacıyla “Dinamik panel veri” tekniği uygulanmıştır. Buna ek olarak, söz konusu ilişki üç farklı göstergesi üzerinden incelenmiştir. saye...

Asset encumbrance is a central concept in the context of banks’ liquidity crises, as it associated with their capacity to obtain secured funding. This occasional paper summarises work carried out by task force on asset encumbrance, bringing together analyses ECB and those national competent authorities working topic. First, we describe how has evolved euro area banks, focusing country business ...