This study was designed to improve the efficacy of radiation therapy against radiation-resistant leukemia. We report that the potency of low dose radiation therapy against B-precursor acute lymphoblastic leukemia (BPL) can be markedly enhanced by combining radiation with a liposomal nanoparticle (LNP) formulation of the SYK-P-site inhibitor C61 ("C61-LNP"). C61-LNP plus low dose total body irra...

We report the anti-leukemic potency of a unique biotargeted nanoscale liposomal nanoparticle (LNP) formulation of the spleen tyrosine kinase (SYK) P-site inhibitor C61. C61-loaded LNP were decorated with a murine CD19-specific monoclonal antibody directed against radiation-resistant CD19-receptor positive aggressive B-precursor acute lymphoblastic leukemia (ALL) cells. The biotargeted C61-LNP w...

A carbohydrate-based fullerene derivative (AcMal7-C61) is designed, synthesized and applied to a lamellar-forming high-χ block copolymer system, poly(3-hexylthiophene)-block-peracetylated maltoheptaose (P3HT-b-AcMal7), actualize an ordered donor/acceptor (D/A) network. well-defined D/A lamellar structure of the P3HT-b-AcMal7:AcMal7-C61 blend with sub-10 nm domain features achieved upon thermal ...

Patients with B-precursor acute lymphoblastic leukemia (BPL) are often treated with TBI-based conditioning, followed by hematopoietic stem-cell transplantation (HSCT). However, the leukemic relapse in high-risk BPL patients remained the major cause of patient mortality (Gaynon et al., 2006; Balduzzi et al., 2014). The incidence of postHSTC relapse correlated with the level of residual leukemia ...

High ON/OFF ratio electrically bistable non-volatile WORM memory devices were prepared based on poly(triphenylamine) with different amounts of pendent PCBM. With the introduction of 10 wt% PCBM into P-TPA via covalent bonding, a memory device with low switching-ON voltage (0.9 V) and high ON/OFF ratio (10(9)) could be obtained. The device performance remained satisfactory under the heating cond...

Article history: Received 8 March 2006 Available online 17 October 2008 JEL classification: C61 C72 C73

Polyoxometalate-bis-pyrene receptors for phenyl-C61-butyric acid methyl ester (PCBM) provide an interfacial layer (IFL) material enhancing the open circuit voltage of organic photovoltaic device about 34% under applied bias ±5 V.

Kim C. Donaghuea, Francesco Chiarellib, Daniela Trottab, Jeremy Allgrovec and Knut Dahl-Jorgensend aThe Children’s Hospital at Westmead, University of Sydney, Australia; bDepartment of Paediatrics, University of Chieti, Italy; cDepartment of Paediatric Endocrinology and Diabetes, Royal London Hospital, Whitechapel, London E1 1BB, UK; dDepartment of Pediatrics, Ullevål University Hospital, and F...

Article history: Received 6 August 2010 Received in revised form 15 November 2010 Accepted 23 November 2010 Available online 2 December 2010 JEL classification: C61 E21 O41

Article history: Received 29 July 2008 Accepted 29 August 2008 Available online 5 September 2008 JEL classification: G11 G10 C61 G19