results hpv-16 e6 and e7 proteins reduced e-cadherin expression 3.7 and 2.2 times when compared with control cells (p = 0.0221 and p = 0.0461, respectively). this reduction was greater in hpv-16 e6-expressing cells than in hpv-16 e7-expressing cells. although hpv-16 e6 and e7 increased dna methyltransferase 1 expression 2.6 and 3.4 times, respectively (p = 0.0133 and p = 0.0113) when compared w...

E-cadherin is among tumor suppressor genes which mostly subjects to the down-regulation in squamous cell carcinoma of esophagus (SCCE). The gene is tightly associated with the tumor invasion and metastasis in multiple human cancers, especially SCCE. CpG islands’ methylation in the promoter region of E-cadherin is among the mechanisms that have been suggested for the E-cadherin silencing, howeve...

e-cadherin is among tumor suppressor genes which mostly subjects to the down-regulation in squamous cell carcinoma of esophagus (scce). the gene is tightly associated with the tumor invasion and metastasis in multiple human cancers, especially scce. cpg islands’ methylation in the promoter region of e-cadherin is among the mechanisms that have been suggested for the e-cadherin silencing, howeve...

objective: e-cadherin is widely down-regulated and tightly associated with tumor invasion and metastasis in multiple human cancer types. recent studies have shown that aberrant methylation of the e-cadherin gene promoter contributes to its silencing. however, information regarding epigenetic inactivation of e-cadherin in colorectal cancer is insufficient. herein, we correlate association of the...

Abstract The endothelial-to-mesenchymal transition (EndMT) is a critical process that occurs during the development of outflow tract (OFT). Malformations OFT can lead to occurrence conotruncal defect (CTD). SOX7 duplication has been reported in patients with congenital CTD, but its specific role remains poorly understood. To decipher this, histological analysis showed SRY-related HMG-box 7 (SOX...

Loss of T-cadherin expression has been reported in a number of human cancers. We previously reported that T-cadherin re-expression suppressed cell growth and motility in glioma. Here, we report that the T-cadherin expression was significantly decreased in human hepatocellular carcinoma (HCC) compared to adjacent normal liver. In addition, T-cadherin expression in HCC with metastasis was signifi...

Kidney-specific cadherin (Ksp-cadherin) is a tissue-specific member of the cadherin family that is expressed exclusively in the kidney and developing genitourinary tract. Recent studies have shown that the proximal 250 bp of the Ksp-cadherin gene promoter are sufficient to direct tissue-specific gene expression in vivo and in vitro. The proximal 120 bp of the promoter are evolutionarily conserv...

Loss of expression of the E-cadherin cell-cell adhesion molecule is important in carcinoma development and progression. Because previous data suggest that loss of E-cadherin expression in breast carcinoma may result from a dominant transcriptional repression pathway acting on the E-cadherin proximal promoter, we pursued studies of cis sequences and transcription factors regulating E-cadherin ex...

The cadherins are cell adhesion molecules required for cellular homeostasis, and N-cadherin is the predominant cadherin expressed in proximal tubular epithelial cells in humans and rats. Our laboratory previously reported an age-dependent decrease in renal N-cadherin expression; the levels of N-cadherin mRNA and protein expression decreased in parallel, implicating a transcriptional mechanism i...

Vascular endothelial cadherin (VE-cadherin) is expressed on vascular endothelial cells, which are involved in developmental vessel formation. However, it remains elusive how VE-cadherin-expressing cells function in postnatal neovascularization. To trace VE-cadherin-expressing cells, we developed mice expressing either green fluorescent protein or LacZ driven by VE-cadherin promoter using Cre-lo...