background: to investigate the effect of cana2-edta and experimental diabetes (iddm) on zinc and carbohydrate metabolism and the activities of got, gpt and alkaline phosphatase. methods: forty male normal albino (wistar) rats of 8 weeks of age were fed with a basal diet. twenty rats were then intraperitoneally injected with alloxan to induce diabetes. then after one week ten rats from each grou...

The majority of snake bites in Central America are caused by Bothrops asper, whose venom induce complex local effects such as myonecrosis, edema and especially hemorrhage. These effects are only partially neutralized by the clinically used antivenom, even when administered rapidly after envenomation. Recently we screened 49 substances for antihemorrhagic activity and found that a mixture compos...

There is considerable clinical evidence that excessive lead absorption causes renal failure with hypertension and predisposes individuals to hypertension even in the absence of detectable renal failure. Recent analyses of transiliac bone biopsies indicate that unsuspected elevated bone leads may reflect the cause (or contributing cause) of end-stage renal disease in 5% of the European dialysis ...

Recent studies found that mutations in the human SLC30A10 gene, which encodes a manganese (Mn) efflux transporter, are associated with hypermanganesemia with dystonia, polycythemia, and cirrhosis (HMDPC). However, the relationship between Mn metabolism and HMDPC is poorly understood, and no specific treatments are available for this disorder. Here, we generated two zebrafish slc30a10 mutant lin...

Military personnel often use ammunitions that contain lead. The present study aimed to identify the risks for lead exposure and lead poisoning among workers at indoor firing ranges. A special health examination, including blood lead level (BLL) testing, was performed for all 120 workers at the indoor firing ranges of the Republic of Korea's Air Force, Navy, and Armed Forces Athletic Corps. The ...

Ultrafine-grained Ti31Mo alloy and Ti31Mo5HA, Ti31Mo5HA-Ag (or Ta2O5, CeO2) composites with a grain size of approximately 2 μm were produced by the application mechanical alloying powder metallurgy. Additionally, surface was modified. In first stage, specimens immersed in 5M NaOH for 24 h at 60 °C. second hydroxyapatite (HA) deposited on sample surface. The cathodic deposition −5 V vs. open cir...

Lead is a heavy metal which is reported to have toxicological effects on various organs in humans and animals. Due to its toxicological effects this study reviews current literature on the toxicological profile of lead on the testis, bone, blood and lungs and the possible roles of mitigating agents. In this study reports showed that in the brain lead induced cerebellar edema, cerebral satellito...