cronkhite-canada syndrome (ccs) is a rare, non-familial disorder of unknown etiology associated with alopecia, cutaneous hyperpigmentation, gastrointestinal polyposis, onychodystrophy, diarrhea, weight loss and abdominal pain.the prevalence ofâ gastrointestinal malignancy in ccs patients is about 13%, and especially is high in colorectal and gastric areas; 5 year mortality rate is 55%. in this ...

cronkhite- canada syndrome (ccs) considered as a rare and non-hereditary disorder. gastrointestinal polyposis and diarrhea along with some extra signs and symptoms such as hypoproteinemia, and epidermal manifestations are recognized in this syndrome. the pathophysiology of this syndrome is not completely understood and it seems that inflammatory processes may be involved. we present a 50 year-o...

ohtahara syndrome or ealy infantile epileptic encephalopathy is a rare cause of epileptic seizures during infancy and represents the earliest type of age related symptomatic generalized epilepsies. the main etiologic factor associated with ohtahara syndrome is cerebran dysgenesis. this case was the product of in vitro fertilization (ivf) after 18 years of infertility . neuroimaging findings con...

BACKGROUND We experienced a case in which Cronkhite-Canada Syndrome presented with complications of multiple gastric cancers and multiple colon adenomas. CASE REPORT Our case is a 64-year-old male who visited a nearby hospital with diarrhea and weight loss. The patient was anemic and hypoproteinemic, with multiple polyps in the stomach, duodenum, and large intestine. He also presented with al...

A 50-year-old woman suffered from anorexia, taste disturbance and a weight loss of 13 kg over a period of 6 months. Physical examination showed onychotrophia (Picture 1), skin pigmentation (Picture 2) and alopecia. Gastroscopy revealed multiple reddish sessile polyps in the antrum and anglus of the stomach (Picture 3). Colonoscopy revealed multiple reddish sessile polyps through the colon and i...

The eighteenth patient and seventh survivor with the Cronkhite-Canada syndrome is described. A remission of 9 years followed gastrectomy and steroid therapy. Findings on seventeen other patients described in the literature are reviewed. The histological features are discussed in detail. The jejunum, though macroscopically normal, showed oedema, increased vascularity and mucous gland secreting a...

The eighteenth patient and seventh survivor with the Cronkhite-Canada syndrome is described. A remission of 9 years followed gastrectomy and steroid therapy. Findings on seventeen other patients described in the literature are reviewed. The histological features are discussed in detail. The jejunum, though macroscopically normal, showed oedema, increased vascularity and mucous gland secreting a...

Cronkhite-Canada syndrome is one of the rare causes of multiple polyposis, characterised by generalised gastrointestinal polyposis, cutaneous hyperpigmentation, alopecia, and nail dystrophy.' Although Cronkhite and Canada described it for the first time in 1955, little is known about its aetiology and the prognosis remains poor. We describe a case of CronkhiteCanada syndrome in a 79-year-old Ja...