it has been shown that enhanced acid secretion can be suppressed in the rat by systemic administration of glucose. we have recently reported that enhancement of acid secretion as a result of pentagastrin was diminished by intragastric administration of d-glucose. present study was designed to investigate whether intragastric d-glucose influences gastric acid secretion associated with carbachol ...

It has been shown that enhanced acid secretion can be suppressed in the rat by systemic administration of glucose. We have recently reported that enhancement of acid secretion as a result of pentagastrin was diminished by intragastric administration of D-glucose. Present study was designed to investigate whether intragastric D-glucose influences gastric acid secretion associated with carbachol ...

Carbachol, a muscarinic receptor agonist, produced three distinct spontaneous oscillations in the CA3 region of rat hippocampal slices. Carbachol concentrations in the 4-13 microM range produced regular synchronized CA3 discharges at 0.5-2 Hz (carbachol-delta). Higher concentrations (13-60 microM) produced short episodes of 5-10 Hz (carbachol-theta) oscillations separated by nonsynchronous acti...

Introduction: Stimulation or inactivation of the lateral hypothalamus (LH) produces antinociception. Studies showed a role for the ventral tegmental area (VTA) in the antinociception induced by LH chemical stimulation through the orexinergic receptors. In this study, we assessed the role of intra-VTA dopamine D1 and D2 receptors in antinociceptive effects of cholinergic agonist, carbachol, m...

Objective: Ziprasidone, aripiprazole, blonanserin, cyamemazine, and nemonapride are atypical antipsychotic drugs used for the treatment of schizophrenia. This study aimed to identify effects these in mice isolated bladder using organ bath systemMaterials Methods: The were injected intraperitoneally with 21 days. investigated on isoproterenol-induced relaxation responses carbachol-induced contra...

Although thyroid hormones are known to influence acid secretion, but exact mechanisms are not fully understood. So, in this experimental study carbachol, histamine, and pentagastrin were used to stimulate acid secretion in isolated stomach of hypo- and hyperthyroid rats and data were compared with controls. Each group consisted of 8 N-Mari rats from both sexes weighing 246 ± 5 g. Hypo- and hype...

The Ca storing site for the carbachol-induced contraction in a high-K medium without adding CaCl2 was further investigated in the guinea pig taenia caecum. La3+ (0.05-0.5 mM) caused an increase in peak tension and relaxation rate in the carbachol contraction but reduced or abolished the response to CaCl2. Simultaneous application of carbachol and CaCl2 produced tension development the trace of ...

Introduction: Previous studies have shown that stimulation of lateral hypothalamus (LH) produces antinociception. Orexin-A (OXA) receptor is strongly expressed in the nucleus locus coeruleus (LC) and orexinergic fibers densely project from LH to LC. In this study, we assessed the role of LC and its OXA receptors in antinociceptive response induced by LH chemical stimulation in the rat. Meth...

Pausawasdi, N., S. Ramamoorthy, V. Stepan, J. Del Valle, and A. Todisco. Regulation and function of p38 protein kinase in isolated canine gastric parietal cells. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G24–G31, 2000.—We examined the regulation and functional role of p38 kinase in gastric acid secretion. p38 kinase was immunoprecipitated from cell lysates of highly purified gastric par...