background cisplatin is an effective antineoplastic drug used extensively in the treatment of malignancies. it induces painful peripheral neuropathy at high doses. objectives the aim of this study was to investigate the effect of carbamazepine (cbz) on cisplatin-induced peripheral neuropathic pain by using the tail-flick test. materials and methods the study was performed using male wistar rats...

the purpose of this study was to compare the effectiveness of three common mood stabilizing drugs, lithium, carbamazepine and valproate in the treatment of acute mania of the 114 patients who participated in this study, 60 were treated with lithium, 30 with carbamazepine and 24 with valproate. this study was a prospective and double blind study. the patients were assessed by gaf scale and a man...

BACKGROUND Carbamazepine is used to treat chronic neuropathic pain. OBJECTIVES Evaluation of analgesic efficacy and adverse effects of carbamazepine for acute and chronic pain management (except headaches). SEARCH STRATEGY Randomised controlled trials (RCTs) of carbamazepine in acute, chronic or cancer pain were identified, searching MEDLINE, EMBASE, SIGLE and Cochrane CENTRAL to June 2010,...

A 20-year-old woman with subacute sclerosing panencephalitis, bedridden because of dystonic posturing and very frequent myoclonic involuntary movements, improved dramatically with carbamazepine. The favorable effect of the carbamazepine on myoclonus was demonstrated by discontinuing and reintroducing carbamazepine, and videoing the consequent reappearance and disappearance of the myoclonus. [Pu...

Acute severe intoxication with carbamazepine is associated with seizures, coma and respiratory depression. Traditionally, charcoal haemoperfusion is used to remove the drug. We present a case of carbamazepine intoxication, successfully treated with three hours of high-flux haemodialysis. Thus, haemodialysis using high-flux membranes is a feasible and effective therapeutic option for carbamazepi...

A suppository for rectal administration of carbamazepine has been developed for situations in which it is unsuitable to use the oral route of administration. In an open, controlled, within-patient study, the pharmacokinetics, clinical efficacy, and tolerability of carbamazepine slow-release tablets were compared with those of carbamazepine suppositories in children with epilepsy. The pharmacoki...

Angioedema is a rare adverse reaction of carbamazepine, which causes localized tissue edema in submucosal and subcutaneous tissue mediated by histamine, serotonin, and kinins (bradykinin). We report a case of 34-year-old female who developed angioedema, 24 h after administration of carbamazepine for treating bipolar disorder. Patient's symptoms responded rapidly with antihistamine therapy and w...

Intracranial section of the glossopharyngeal and upper roots of the vagus nerves has been recommended, the cardiac dysrhythmia being controlled with atropine, isoprenaline, or transvenous pacemaker. Carbamazepine is known to relieve the pain of uncomplicated glossopharyngeal neuralgia.2 In our first patient the combination of carbamazepine and demand pacemaker abolished both pain and syncope wi...