Quinoline-2-carbohydrazide (3) was reacted with aryl or alkyl isothiocyanates to give the corresponding quinoline thiosemicarbazides (4a-e). Cyclization of the substituted thiosemicarbazides with sodium hydroxide led to the formation of 5-(quinolin-2-yl)2H-1, 2, 4-triazole-3(4H)-thiones (5a-e). Desulfurization of thiosemicarbazides by mercuric oxide gave 5-(quinolin-2-yl)-1, 3, 4-oxadiazol2-ami...

This work includes synthesis a series of some new derivatives triazine from reaction between the sulfur amino acid (L-cysteine) and different aldehydes in dry ethanol to obtain thiazolidine ring as diastereo isomers (Cis Trans)- 2- alkylthiazolidine-4- carboxylic acids (1).
 The (1) suffered esterfication presence drops concentrated sulfuric catalyst give esters :
 ethyl alkylthiazoli...

The synthesis of novel mercury (II) complex with new ligands derived from Carbohydrazides has been reported. The complexes have general composition [ HgL2X2], Where L= Carbohydrazone and X = Cl-, NO3 . The ligand carbohydrazone behave as neutral bidentate Ligand through the carbonyl oxygen and azomethiene nitrogen. On the basis of elemental analysis, Electrochemical and spectroscopic studies, t...

The synthesis and antiproliferative activity of new benzimidazole derivatives bearing an hydrazone mojety at the 2-position is described. The new N'-(4-arylidene)-1H-benzo[d]imidazole-2-carbohydrazides were evaluated for their cytostatic activity toward the murine leukemia (L1210), human T-cell leukemia (CEM), human cervix carcinoma (HeLa) and human pancreas carcinoma cells (Mia Paca-2). A prel...

Thiophene containing thiazolyl carbohydrazide on reaction with various aryl isothiocynates yields thiosemicarbazides which were transformed into 1,2,4- substituted thiazoles by Hantzsch synthesis and characterized spectral methods. Most of the synthesized new are found to be promisingly effective against tested bacterial strains exhibited moderate activitytested fungal strains. 1, 2,4- weakly a...

Although salicylaldehyde azine (3) was reported in 1985 as the single product of the reaction of ethyl 2-oxo-2H-chromene-3-carboxylate (1) with hydrazine hydrate, we identified another main reaction product, besides 3, which was identified as malono-hydrazide (4). In the last two decades, however, some articles have claimed that this reaction afforded exclusively hydrazide 2 and they have repo...

We report the conformational analysis of a series of 3-hydroxy-N'-((naphthalen-2-yl)methylene)naphthalene-2-carbohydrazides. This class of compounds has recently been reported as androgen receptor (AR)-coactivator disruptors for potential application in prostate cancer therapy. Definition of the E/Z isomerism around the imine linker group (hydrazide) is significant from a mechanistic point of v...

A method was proposed for the synthesis of substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids by reaction 2,4-dioxobut-2-enoic with furan-2-carbohydrazide. It found that undergo intramolecular cyclization in presence propionic anhydride to form corresponding N'-(2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides. The anti-inflammatory activity obtained compounds studied. have prono...