Although it has been observed that aggregate size affects cardiac development, an incomplete understanding of the cellular mechanisms underlying human pluripotent stem cell-derived cardiomyogenesis has limited the development of robust defined-condition cardiac cell generation protocols. Our objective was thus to elucidate cellular and molecular mechanisms underlying the endogenous control of h...

Abstract Background and Objective: It has been shown that oxidative stress increases in diabetes and it has an important role in its development and subsequent complications. Thus, the aim of this study was to investigate the effect of acute resistance exercise on oxidative stress in skeletal muscle and cardiac tissues of streptozotocin-induced diabetic rats. Materials and Methods: Twenty male ...

the acute diffuse hypoxia in dogs by general hypoxia, ligation of the coronary arteries and perfusion of the coronaries in the diffuse hypoxic hear ts. t he results of our experiments suggest that the quantitative diminu tion of oxygen and bloo d supply to the myocardium is, rather than oxygen differential , a determining fa ctor for development of ventr icular fi brillat ion or cardiac arrest.

background: reintubation in patients after cardiac surgery is associated with undesirable consequences. the purpose of the present study was to identify variables that could predict reintubation necessity in this group of patients. methods: w e performed a prospective study in 1000 consecutive adult patients undergoing cardiac surgery with cardiopulmonary bypass. the patients who required reint...

objective(s): menopause and diabetes obviously increase the risk of cardiovascular disease in women. the aims of the present study were to evaluate the effects of ovariectomy in type 2 diabetes on the histology and expression of mirna-29, mirna-133, igf-1 and bcl-2 genes and bcl-2 protein and caspase 3 activity in the hearts of female rats. materials and methods: forty female wistar rats were d...

abstract background: aprotinin has been used increasingly to reduce postoperative blood loss in open-heart operations due to the potentialities for complications and high cost, it would seem reasonable to use aprotinin more selectively in small doses in the prime solution of the pump. methods: we prospectively studied the effect of preoperative low dose aprotinin [2 million units (230mg)] on bl...

the most frequent congenital heart defects in the neonatal period are ventricular septal defects. ventricular septal aneurysms can rarely develop from an interventricular septal (ivs) defect in adults. we describe a 47-year-old man with an aneurysm in the ivs growing towards the right ventricle, which was confirmed by cardiac computed tomographic angiography and was missed by echocardiography.

from march 1990 to may 1993,309 patients underwent redo cardiac surgery operation at the shahid rajai heart hospital in tehran. early mortality rates in these patients showed a significant increase in comparison to patients undergoing open heart surgery for the first time. late mortality (at least one month after surgery) in the patients was slightly increased also but less than early mortality...

Cardiac development proceeds via the activation of a complex network of regulatory factors which both directly and indirectly impact downstream cardiac structural genes. In Drosophila, the NK homeodomain transcription factor Tinman is critical to cardiac specification and development via the activation of a number of key regulatory genes which mediate heart development. In this manuscript, we d...