depression is a serious disorder in today’s society, with the estimates of lifetime prevalence being as high as 21% of the general population in some developed countries. as defined by the american psychiatric association, depression is a heterogeneous disorder often manifested with symptoms at the psychological, behavioral, and physiological levels. such patients are often reluctant to take sy...

multiple sclerosis (ms) is a chronic auto-immune disease. most therapeutic strategies for treatment of this disease direct immune modulation and control of inflammatory processes. first-line therapeutic agents showed moderate efficacy and frequent side-effects with moderate efficacy in trials. their parental administration and limited long-term adherence restrict their efficacy compared with se...

Since 1976, benfluorex has been approved in Europe as a hypolipidemic and hypoglycemic drug, and is commonly used in the treatment of the metabolic syndrome. As a derivative of fenfluramine with an appetite suppressant action, benfluorex is preferentially used in overweight patients. In contrast to fenfluramine and dexfenfluramine, to date, benfluorex has not been reported to be associated with...

Recent advances in chemotherapy have substantially improved the prognosis of cancer patients. However, many anticancer drugs, especially newly developed ;molecular-target drugs', such as the anti-HER2 blocking antibody and the anti-vascular endothelial growth factor antibody, have serious cardiovascular side-effects such as heart failure, thromboembolism, severe hypertension and lethal arrhythm...

We review the cardiovascular effects of newer antidepressants. Although further studies are warranted, the safety of the selective serotonin reuptake inhibitors and the serotonin norepinephrine reuptake inhibitors on patients with comorbid cardiac conditions is impressive. Newer antidepressants should be considered as first-line agents for the treatment of depression in patients with and withou...

introduction: ifosfamide (ifo) is a potent drug that is used in cancer therapy. the major uses of ifo are: solid tumors especially, osteogenic sarcoma, other soft tissue sarcomas and hematologic malignancy, especially in lymphoma patients. the toxicity of ifo is very encompassing and includes: alopecia, nausea, vomiting, gastrointestinal, renal and neurological problems. neuropsychiatric toxici...

results anxiety, as the second most common reason of psychiatric disorders in cases of poisoning, with a prevalence of 12.1% in form of mild, 75.9% moderate and 12.1% severe, was confirmed among the participants of this study. conclusions the prevalence of anxiety among cases of poisoning with both drugs and chemicals are noticeably higher than general population. this fact strongly suggests th...