AIMS Major aims were to determine whether exposure to the commonly used food additive carrageenan could induce fasting hyperglycemia and could increase the effects of a high fat diet on glucose intolerance and dyslipidemia. METHODS C57BL/6J mice were exposed to either carrageenan, high fat diet, or the combination of high fat diet and carrageenan, or untreated, for one year. Effects on fastin...

Colonic mucosal lesions, characterized by crypt abscesses and mononuclear cell infiltration, which resemble human ulcerative colitis can be induced in rabbits by short-term (7 to 8 weeks) administration of carrageenan according to our method. In this study experimental epithelial dysplasia of the colon was induced by the p.o. administration of lambda-degraded carrageenan for a much longer perio...

Carrageenan produces both inflammation and pain when injected in mouse paws via enhancement of reactive oxygen species formation. We have investigated an effect of astaxanthin extracted from Litopenaeus vannamei in carrageenan-induced mice paw edema and pain. The current study demonstrates interesting effects from astaxanthin treatment in mice: an inhibition of paw edema induced in hind paw, an...

Here we investigate the effects of the green tea extract in an animal model of acute inflammation, carrageenan-induced pleurisy. We report here that green tea extract (given at 25 mg/kg i.p. bolus 1 h prior to carrageenan), exerts potent anti-inflammatory effects in an animal model of acute inflammation in vivo. Injection of carrageenan (2%) into the pleural cavity of mice elicited an acute inf...

Evaluation of the effect of hydroalcoholic extracts of Cassia occidentalis in paw edema induced by Carrageenan in Rats. The effect of oral administration of hydroalcoholic extract of Cassia occidentalis seeds on carrageenan induced inflammation has been studied and is compared with the effect of oral administration of Diclofenac sodium as standard on rats. A carrageenan resulted in paw edema. S...

The aim of this study was to test antinociceptive properties of venlafaxine in rats with carrageenan-induced pain and inflammation. Pain was provoked with carrageenan (1%) injection into the plantar surface of the rat paw-pad. The effect of venlafaxine on carrageenan-induced mechanical hypersensitivity, mechanical stimulation response (the von Frey monofilament test) as well as the size of carr...

Various medicinal plants are used in traditional system of medicine to treat various diseases and many of these plants have been evaluated for their different pharmacological activities. Borassus Flabellife is one among them. The present study was planned to investigate Antiinflammatory effect of Borassus Flabellife ethanolic extract of root. Acute inflammation was produced by injecting 0.1 ml ...

BACKGROUND Polyphenols from olive are known to possess antioxidant and anti-inflammatory properties. AIM The aim of this study was to study whether or not 10 consecutive days i.p. administration of a blend of olive (Olea europaea L.) polyphenols (10 mg/kg) containing mostly hydroxytyrosol could have an effect on cytokines playing important roles in inflammatory processes as TNF-α and IL-10. ...

canarium l. is used in folk medicine as anti-inflammatory, antibacterial, antifungal, antitumor, heptoprotective, antioxidant, and anti diabetic properties. the present study investigeated the invivo anti-inflammatory activity of  essential oil obtained by hydrodistillation of resin of canarium strictum roxb. in the current study, anti-inflammatory activity of essential oil of canarium strictum...