objective(s): regulatory t cells, including cd4+cd25+fox3+ and cd8+cd28- cells play an important role in regulating the balance between immunity and tolerance. since multiple sclerosis is an inflammatory autoimmune disease, regulatory t cells are considered to be involved in its pathogenesis. in this study, we investigated the circulatory numbers of the two mentioned types of regulatory t cells...

mitochondrial functions have a major impact on t-cell functionality. in this study we characterized whether mitochondrial function in the neonatal t-cells differs from that in the adult t-cells during short t-cell activation. methods: we used fow cytometry methods to test mitochondrial mass and to monitor mitochondrial ca2+ levels, mitochondrial potential and superoxide generation in parallel w...

brucellosis is an infectious disease and it seems that it affects human immune system and can cause acute, subacute and chronic clinical features. forty patients suffering from chronic brucellosis were studied for cd3+, cd4+,cd8+, cd19+, cells and cd4+/cd8+ ratio by flow cytometry before and after treatment with antibiotics and immunopotentiators. the results were compared with 15 healthy contr...

local inflammatory processes in the gastric mucosa are followed by extensive immune cell infiltration, resulting in chronic active gastritis characterized by a marked infiltration of t(h)1 cytokine-producing cd4+ and cd8+t-cells objective. to investigate the correlation between cd4+/cd8+ t-cells in gastric mucosa with endoscopic appearance in chronic gastritis with or without h.pylori infection...

abstractbackgroundcontributes substantially to patient morbidity and mortality.in this study we investigatedthe range and distribution of t-lymphocyte. subsets cd3helper/inducer cell,.th ), cd8: severe immunosuppression occurs after large thermal burn and probably+ (t cells) cd4+ (t+ (t suppressor /cytotoxic cells ,ts/c), cd3+cd4thermal injury.+/cd3+cd8+ ratio, cd19+ (b cells) and cd16+ (nk cel...

background: determination of the division history of t cells in vitro is helpful in the study of effector mechanisms against infections. technique described here uses the intracellular fluorescent label carboxyfluorescein diacetate succinimidyl ester (cfse) to monitor the proliferation. methods: in a cross sectional study, blood samples were collected from 7 volunteers with history of cutaneous...

Objective(s): In this study, we aimed to investigate the effects of anti-Fas ribozyme on the apoptosis of T lymphocytes (T cells) in mice model with chronic obstructive pulmonary disease (COPD). Materials and Methods: Male 6-week-old C57BL/6 mice were used to establish the COPD model by exposure to cigarette smoke. The COPD mice were sacrificed for spleen dissection and T cell isolation. T cell...