patients and methods for this clinical trial, patients with fever plus either dysuria, frequency, flank pain or flank tenderness were enrolled. having performed urinalysis (u/a), urine culture (u/c) and antibiogram, they were randomly assigned in two groups: ceftriaxone 1gr twice a day or cefazolin 1gr trice a day. three days later, urine was re-evaluated and patients were categorized as clinic...

conclusions: considering the low rate of ceftriaxone resistance amongst isolated pneumcocci.in this study, only ceftriaxone treatment of adult patients with invasive pneumococcal infections (other than cns infections) is sufficient; but pediatric patients and patients with cns infections should be treated with ceftriaxone and vancomycin. apparently, diminution of vancomycin use can be resulted ...

Ceftriaxone is widely used in patients for the treatment of serious gram-negative infections. Ceftriaxone can induce some potential side effects, including neurotoxicity, however, nonconvulsive status epilepticus has rarely been reported. We report a case of acute reversible neurotoxicity associated with ceftriaxone. A 65-yr-old woman with chronic kidney disease developed altered consciousness ...

Seventeen patients who underwent vitreal surgery received ceftriaxone (Rocephin) 1-2 g intramuscularly at various time intervals before surgery. Specimens of serum and vitreous were assayed for ceftriaxone concentrations both by bioassay and high pressure liquid chromatography. All patients had detectable vitreous (and serum) ceftriaxone concentrations at all time periods. Vitreous ceftriaxone ...

background and purpose: progressive degeneration of dopaminergic neurons in the midbrain is the main mechanism of parkinson’s disease (pd). recent studies have shown ceftriaxone, a β-lactam antibiotic, to be a neuroprotective in various neurodegenerative disorders. hence, the present study aimed to investigate the effect of ceftriaxone on behavioral disturbances of pd in an animal model. method...

Ceftriaxone is among the most commonly utilized antibiotics owing to its high potency, wide spectrum of activity, and low risk of toxicity. It is used to treat different types of bacterial infections including pneumonia, bone infections, abdominal infections, Skin and soft tissue infections, urinary tract infections. However, evidence around the globe shows the misuse of Ceftriaxone. This study...

OBJECTIVES This study aimed to demonstrate if the addition of anti-inflammatory treatment to antibiotic therapy shows any superiority to the treatment with antibiotic only. METHODS Forty-nine Wistar rats were divided into 7 groups. Pyelonephritis was performed by E. coli injection to upper pole of kidneys except control group. Group 2 was not treated. Ceftriaxone, ketoprofen, "ceftriaxone + k...

We conducted a systematic review and meta-analysis of ceftriaxone for treatment of uncomplicated gonorrhoea compared with four other antibiotics. Thirteen randomized controlled trials (RCTs) totalling treatment of 2557 patients with uncomplicated gonorrhoea were included. Statistically significant differences were observed in side-effects, which were increased after ceftriaxone 250 mg versus ce...

The in vitro activities of penicillin and ceftriaxone were compared against 29 strains of Streptococcus pyogenes with the result that ceftriaxone showed greater activity than penicillin. The morphological changes induced by 1/2 and 1x MIC concentrations of penicillin and ceftriaxone, respectively, were very similar using scanning electron microscopy. Competitive binding studies using 'cold' pen...