the p53 protein function is essential for the maintenance of the nontumorigenic cell phenotype. pancreatic tumor cells show a very high frequency of p53 mutation. to determine if restoration of wild type p53 function can be used to eliminate the tumorigenic phenotype in these cells, pancreatic tumor cell lines, panc-1 and htb80, differing in p53 status were stably transfected with exogenous wil...

objective(s):various methods for repairing bone defects are presented. cell therapy is one of these methods. bone marrow stromal cells (bmscs) seem to be suitable for this purpose. on the other hand, lots of biomaterials are used to improve and repair the defect in the body, so in this study we tried to produce a similar structure to the bone by the chitosan and hydroxyapatite. materials and me...

background: the canonical wnt signal transduction (or the wnt/β-catenin pathway) plays a crucial role in the development of animals and in carcinogenesis. beta-catenin is the central component of this signaling pathway. the activation of wnt/β-catenin signaling results in the cytoplasmic and nuclear accumulation of β-catenin. in the nucleus, β-catenin interacts with the tcf/lef transcription fa...

background: niche cells, regulating spermatogonial stem cells (sscs) fate are believed to have a reciprocal communication with sscs. the present study was conducted to evaluate the effect of ssc elimination on the gene expression of glial cell line-derived neurotrophic factor (gdnf), fibroblast growth factor 2 (fgf2) and kit ligand (kitlg), which are the main growth factors regulating sscs deve...

Background: Paenibacillus larvae is the etiological agent of American foulbrood (AFB) disease, the most lethal disease in honeybee (Apis mellifera) larvae. Aims: The aim of the present work was to study the antimicrobial effect of cell free supernatant (CFS) of probiotics on an Iranian isolate’s biofilm formation. Methods: A l...

Background: Neutrophils are the most abundant white blood cells in humans. Recently, a novel strategy called the formation neutrophil extracellular traps (NETs) was described. NETs is a new strategy for pathogen response. This study focused on whether LPS induced NETs release in vitro in the HL60 cell line. Methods: In this study, the HL60 cell line was used for culture and DMSO for induction ...

Design of Cellular Manufacturing System involves four major decisions: Cell formation (CF), Group layout (GL), Group scheduling (Gs) and Resource assignment (RA).  These problems should be regarded, concurrently, in order to obtain an optimal solution in a CM environment. In this paper a two stage heuristic procedure is proposed for CF and RA decisions problem. The solution approach contains a ...

Optimization of the complete manufacturing and supply process has become a critical ingredient for gaining a competitive advantage. This article provides a unified mathematical framework for modeling manufacturing cell configuration and raw material supplier selection in a two-level supply chain network. The commonly used manufacturing design parameters along with supplier selection and a subco...

This paper addresses to the Cell Formation Problem (CFP) in which Automated Guided Vehicles (AGVs) have been employed to transfer the jobs which may need to visit one or more cells. Because of added constraints to problem such as AGVs’ conflict and excessive cessation on one place, it is possible that AGVs select the different paths from one cell to another over the time. This means that the ti...

To enhance agility and quick responding to customers' demand, manufacturing processes are rearrenged according to different systems. The efficient execution of a manufacturing system depends on various factors. Among them, cell design and human issue are the pivotal ones. The proposed model designs cellular manufacturing systems using three objective functions from three different perspectives,...