In the present study, the effect of NBM lesion on the temporal characteristics of response integration evoked by multiple whisker stimulations in the barrel cortex of rats was studied. Nucleus basalis of Meynert (NBM) projects to widespread areas of the cortex and provides the major cholinergic input (80%) to the cerebral cortex. In this study we examined the effects of NBM lesion on the respon...

Objective(s):Acrylamide (ACR) has many applications in different industries. ACR damages the central and the peripheral nervous system in human and animals. Importance of ACR-induced neurotoxicity encouraged researchers to find both different mechanisms involved in ACR neurotoxicity and potent neuroprotective agents. Therefore, this study was designed to investigate the protective effect of cro...

Objective(s):Acrylamide (ACR) has broad applications in different industries. It also forms in food during heating process. Oxidative stress has a critical role in ACR-induced neurotoxicity in both in vitro and in vivo models; therefore, the aim of the current study was the evaluation of effects of thymoquinone, the main constituent of volatile oil from Nigella sativa seeds in ACR-induced neuro...

Background: It has been suggested that organophosphates may inhibit gamma-aminobutyric acid (GABA) metabolism in synaptosomal preparations. In the present investigation, we have assessed the interaction between paraoxon and the GABA system at synaptic level. Methods: Synaptosomes were prepared from male Wistar rats (200-250 g). Cerebral cortex was dissected and homogenized, then centrifuged at ...

Background: The study aims to evaluate the impact of the antioxidant rich pomegranate fruit grown in Taif on the histological and immunohistochemical changes in the cerebral and cerebellar cortex after different levels of mobile exposure. Materials and Methods: Thirty adult male rats were divided into group I, II, III; IV, and group V. Group I was control and group II rats were exposed to 900 M...

The primary cilium, a microtubule based organelle protruding from the cell surface and acting as an antenna in multiple signaling pathways, takes center stage formation of cerebral cortex, part brain that performs highly complex neural tasks confers humans with their unique cognitive capabilities. These activities require dozens different types neurons are interconnected ways. Due to this compl...