نتایج جستجو برای: cholestatic rat

تعداد نتایج: 277745  

Journal: :Journal of Visualized Experiments 2011

2016
Yauheniya Cherkas Michael K. McMillian Dhammika Amaratunga Nandini Raghavan Jennifer C. Sasaki

As legacy toxicogenomics databases have become available, improved data mining approaches are now key to extracting and visualizing subtle relationships between toxicants and gene expression. In the present study, a novel "aggregating bundles of clusters" (ABC) procedure was applied to separate cholestatic from non-cholestatic drugs and model toxicants in the Johnson & Johnson (Janssen) rat liv...

Ahmad Reza Dehpour, Ehsan Salimi Fatemeh Nabavizadeh, Hossein Nahrevanian, Kaveh Shahvaisi Rohallah Moloudi

Objective(s) The liver has major role in the organism homeostasis, interactions with other systems, synthesis and metabolism of bile production, drug detoxification and hormone inactivation. Cholestasis can be defined as an impairment of the bile flow which can lead to hepatocytes necrosis and finally cirrhosis. Some studies reported a gastric acid secretion reduction in cirrhotic subjects, wh...

Journal: :iranian journal of basic medical sciences 0
fatemeh nabavizadeh department of physiology, tehran university of medical sciences, tehran, iran rohallah moloudi department of physiology, tehran university of medical sciences, tehran, iran ahmad reza dehpour department of physiology, tehran university of medical sciences, tehran, iran hossein nahrevanian pasteur institute of iran, tehran, iran kaveh shahvaisi department of physiology, tehran university of medical sciences, tehran, iran ehsan salimi tehran university of medical sciences, tehran, iran

objective(s) the liver has major role in the organism homeostasis, interactions with other systems, synthesis and metabolism of bile production, drug detoxification and hormone inactivation. cholestasis can be defined as an impairment of the bile flow which can lead to hepatocytes necrosis and finally cirrhosis. some studies reported a gastric acid secretion reduction in cirrhotic subjects, whi...

2008
María-Angeles Aller Luis Ortega Fernando Sánchez-Patán Raquel Anchuelo Arturo Cruz Manuel Losada Jaime Arias

Fibrosis, bile duct proliferation and mast cell hyperplasia characterize extrahepatic cholestasis. We studied these liver alterations in a new microsurgical model of extrahepatic cholestasis in the rat. Male Wistar rats: Sham-operated (n=9) and Microsurgical Cholestasis (n=10). After 4 weeks, a liver morphometric study was carried out using an image analysis system to assess bile proliferation ...

Journal: :Journal of hepatology 2003
Marieke H Schoemaker Willemijn M Gommans Laura Conde de la Rosa Manon Homan Pieter Klok Christian Trautwein Harry van Goor Klaas Poelstra Hidde J Haisma Peter L M Jansen Han Moshage

BACKGROUND/AIMS To examine the extent and mechanisms of apoptosis in cholestatic liver injury and to explore the role of the transcription factor nuclear factor-kappa B in protection against bile acid-induced apoptosis. METHODS Cholestatic liver injury was induced by bile duct ligation in Wistar rats. Furthermore, primary cultures of rat hepatocytes were exposed to glycochenodeoxycholic acid ...

2010
J. Ulloa S. Stahl N. Woodhouse G. Healing G. Kenna J. C. Waterton P. Hockings

INTRODUCTION One of the major patterns of drug-induced liver injury (DILI) observed in man is cholestatic DILI. The mechanisms are complex and include decreased bile formation, which results in increased bile acid levels in blood [1]. Hepatobiliary transporters mediate uptake and excretion of drugs and endogenous substances. It has been proposed that inhibition of biliary efflux transporters ma...

Journal: :The Journal of clinical investigation 1993
R Bossard B Stieger B O'Neill G Fricker P J Meier

We investigated the effects of 17 alpha-ethinylestradiol treatment of rats on various transport functions in isolated basolateral and canalicular liver plasma membrane vesicles. Both membrane subfractions were purified to a similar degree from control and cholestatic livers. Although moderate membrane lipid alterations were predominantly observed in basolateral vesicles, no change in basolatera...

Journal: :The Journal of clinical investigation 2003
Yaping Liu Jane Binz Mary Jo Numerick Steve Dennis Guizhen Luo Bhasha Desai Kathleen I MacKenzie Traci A Mansfield Steven A Kliewer Bryan Goodwin Stacey A Jones

Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor superfamily. Fxr-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver, activation of FXR induces transcription of transporter genes involved in promoting bile acid clearance and represses genes involved in bile acid bi...

2017
Jimme K. Wiggers Rowan F. van Golen Joanne Verheij Annemiek M. Dekker Thomas M. van Gulik Michal Heger

BACKGROUND Extrahepatic cholestasis sensitizes the liver to ischemia/reperfusion (I/R) injury during surgery for perihilar cholangiocarcinoma. It is associated with pre-existent sterile inflammation, microvascular perfusion defects, and impaired energy status. Statins have been shown to protect against I/R injury in normal and steatotic mouse livers. Therefore, the hepatoprotective properties o...

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