introduction: cisplatin is an antineoplastic drug, which is widely used for the treatment of solid tumors. however, its clinical usage is limited because of its side effects such as hepatotoxicity. this study aimed to identify toxic effects of cisplatin on hepatocytes of rats. methods: a total of 45 adult sprague dawley rats weighing 200±30 g were randomly divided into experimental (n=30) and c...

Platinum is a metallic element, which may react with our cellular component through its involvement in cancer chemotherapy medications. Cisplatin is one of the most useful antineoplastic drugs against human ovarian carcinoma, which has the central element of platinum in its structure. The nature of chemical interaction between platinum and cellular macromolecules is yet to be understood. We exa...

We attempt to study the short-term efficacy of tislelizumab+carboplatin/cisplatin+pemetrexed in advanced lung adenocarcinoma and its effect on tumor markers. Retrospectively analyzed clinical data 68 patients admitted our hospital from May 2019 June 2021 divided them into control group (n=34) (n=34). Treated with carboplatin or cisplatin+pemetrexed, while treated tislelizumab+carboplatin cispla...

The research study was designed to compare the safety and efficacy of the regimen of 5-flurouracil with cisplatin of investigational arm with the reference regimen of gemcitabine with cisplatin for the treatment of gallbladder cancer. A total of 60 patients were enrolled in the study. Out of 30 patients enrolled in arm-A (Gemcitabine with Cisplatin) and 30 patients enrolled in arm-B (5-Fluroura...

Nephrotoxicity and hepatotoxicity are frequently seen adverse effects during cisplatin chemotherapy. In this study, we investigated the of agomelatine on cisplatin-induced toxicity in kidney liver. Animals were administered with a single dose (7 mg/kg, i.p.) treated (20 40 p.o) for seven days. Renal hepatic functions evaluated by measuring concentrations creatinine, BUN, AST ALT serum. Oxidativ...

Mục tiêu: 1. Nhận xét một số đặc điểm lâm sàng, cận sàng của nhóm bệnh nhân ung thư phổi không tế bào nhỏ (UPKTBN) giai đoạn IB-IIIA. 2. Đánh giá kết quả điều trị phẫu thuật và hóa chất bổ trợ phác đồ bộ đôi platinum trên UTPKTBN Bệnh phương pháp nghiên cứu: Nghiên cứu hồi cứu, cắt ngang, 60 IB-IIIA được vinorelbine/ pemetrexed-cisplatin sau triệt căn tại viện K từ tháng 1/2019 đến 9/2022. Kết ...

The testes are highly susceptible to the adverse effects of chemotherapy and radiation at all stages life. Exposure these threats mainly occurs during cancer treatment as an occupational hazard in centers. present study investigated regenerative ability adipose-derived mesenchymal stem cells (ADMSCs) against cisplatin on structure function testes. New Zealand white male rabbits (N = 15) were di...

Objective: In the current investigation, we aimed to study the combined cytotoxicity of curcumin, as a nanomicellar formulation, and galbanic acid (Gal), dissolved in DMSO against the murine C26 and human Caco-2 colon carcinoma cells. Further, curcumin potential for cisplatin and doxorubicin (Dox) co-therapy was studied. <span styl...

Background Cisplatin is a common platinum based chemotherapy drug that is commonly used for the treatment of the solid tumors. It is believed that this drug has nephrotoxic effects due to its oxidative action. Therefore, it is believed antioxidant agents such as vitamin...

Cisplatin is one of the most used first-line anticancer drugs for various solid tumor therapies. However, cisplatin-based chemotherapy can induce cells to secrete excessive prostaglandin E2 (PGE2) catalyzed by cyclooxygenase-2 (COX-2), which, in turn, counteracts its chemotherapeutic effect and further accelerates metastasis. Here, we report a carrier-free self-delivered nanoprodrug based on pl...