Thirteen isolates of Cladobotryum spp., isolated from diseased fruiting bodies of Agaricus bisporus, sampled from mushroom farms in Serbia during 2003-2006, were studied. Sensitivity to several selected fungicides was tested and all isolates were found to be highly sensitive to iprodione (EC50 = 0.35-2.30 mg L-1), benomyl (EC50 = 0.14-0.97 mg L-1) and especially to prochloraz-Mn (EC50 = 0.02-0....

CJ-15,696 and 7 novel furopyridine antibiotics were isolated from the fungus Cladobotryum varium CL12284. Their structures were determined by X-ray crystallography and spectral analysis. Three biotransformed analogs were also prepared from CJ-15,696. CJ-15,696 showed moderate activity against various Gram-positive bacteria including some drug resistant strains such as methicillin resistant Stap...

Two antimicrobial metabolites were isolated from submerged cultures of Cladobotryum rubrobrunnescens, a mycophilic fungus growing on a Inocybe species. One of the compounds proved to be identical to flavipucine (2), an antibiotic previously isolated from Aspergillus flavipes (Casinovi et al., 1968) and from a Macrophoma species (Sassa T. and Onuma Y. (1983), Agric. Biol. Chem. 47, 1155-1157). T...

During 2003-05 Iranian provinces in the Southern Caspian coast (Gilan, Mazandaran and GolestanProvinces, N. Iran) were investigated in order to collect and identify fungicolous species on various fungal hosts. Fifty-seven isolates were obtained and these were classified into seven genera, Acremonium, Cladobotryum, Fusarium, Sepedonium, Hypomyces, Lecanicillium, Simplicillium and Trichoderma. Am...

Three Hypomyces and one Cladobotryum species are studied and reported as new records and also new anamorph/teleomorph connections of fungicolous fungi for Iran. Anamorphs of two species H. aurantius and H. rosellus (Cladobotryum varium and C. dendroides, respectively) have already been reported from Iran. The anamorph/teleomorph association of H. polyporinus/C. clavisporum was also found and wa...

Cladobotryum dendroides (= Dactylium dendroides) has hitherto been regarded as the major causal agent of cobweb disease of the cultivated mushroom, Agaricus bisporus. Nucleotide sequence data for the internal transcribed spacer (ITS) regions of four Cladobotryum/Hypomyces species reported to be associated with cobweb disease, however, indicate that the most common pathogen is now C. mycophilum....

FR901483, a novel immunosuppressant, has been isolated from the fermentation broth of Cladobotryum sp. No. 11231. The molecular formula of FR901483 has been determined as C20H31N2O6P. FR901483 exerts a potent immunosuppressive activity in vitro and significantly prolongs graft survival time in the rat skin allograft model. This compound has an intriguing tricyclic structure possessing a phospha...