BACKGROUND Persons being treated with IFNalpha-2b for advanced cutaneous malignant melanoma (CMM) have been reported to have a greatly improved prognosis if they develop autoantibodies or clinical signs of autoimmunity during therapy. Consequently, we examined whether autoimmune diseases might also be associated with lower CMM incidence and better prognosis. METHODS We established a study coh...

The presentations of primary and metastatic cutaneous malignant melanoma (CMM) are very diverse. Evidence increasingly indicates that single CMM cells spread to distant sites quite early during cancer progression and are soon eliminated before they become clinically detectable. However bulky metastases which appear at a later stage might derive from some of these early neoplastic cells. It seem...

In recent years, rapid advances were reached in the understanding of a series of biologic signals influencing cutaneous malignant melanoma (CMM) cells. CMM is in close contact with a peculiar dermal extracellular matrix (ECM). Stromal cells store and release various structural ECM components. The impact on CMM growth and progression is mediated through strong and long-lasting effects of ECM pro...

Cooperative map matching (CMM) uses the Global Navigation Satellite System (GNSS) position information of a group of vehicles to improve the standalone localization accuracy. It has been shown, in our previous work, that the GNSS error can be reduced from several meters to sub-meter level by matching the biased GNSS positioning to a digital map with road constraints. While further error reducti...

CMM found its genesis in Software Engineering Institute (SEI), Carnegie Mellon University, USA . It was formulated mainly because the existing ISO standard was not suitable for the Software Industry. Today CMM is widely used and is considered to be the most prestigious standard in software industry. USA and Indian software companies were the first to adopt CMM. However given the cultural simila...

The mu and theta classes of glutathione S-transferases (GST) may affect the development of cutaneous malignant melanoma (CMM) by decreasing cellular oxidative stress in skin. These isozymes are absent in a large proportion of the population because of germ-line homozygous deletions in the genes encoding GSTM1 and GSTT1. To determine the association between GSTM1 and GSTT1 homozygous deletions (...

The main aim of this research is to determine the best material for manufacturing of steering knuckle in order to reduce the weight using aluminum alloy and Metal Matrix Composite (MMC). To achieve this purpose, the Modal test has been performed to study vibrational behavior of steering knuckle. CAD Model has been prepared by using coordinate measuring machine (CMM). Finally, the Finite Element...