Green synthesis of mPEG–PLGA and nanoformulation for delivery irinotecan to colon cancer.

primula auriculata (tootia) is one of the most important local medicinal plants in hamedan district, iran. to investigate cytotoxicity and apoptosis induction of crude methanolic extract and different fraction of it we compared several methods on ht-29 human colon adenocarcinoma cells. cancer cell proliferation was measured by 3-(4, 5‑dimethylthiazolyl)-2, 5‑diphenyl‑tetrazolium bromide (mtt) a...

Cancer is a fatal disease caused by combination of genetic diseases and variety biochemical abnormalities. Lung colon cancer have emerged as two the leading causes death disability in humans. The histopathological detection such malignancies usually most important component determining best course action. Early ailment on either front considerably decreases likelihood mortality. Machine learnin...

Primula auriculata (Tootia) is one of the most important local medicinal plants in Hamedan district, Iran. To investigate cytotoxicity and apoptosis induction of crude methanolic extract and different fraction of it we compared several methods on HT-29 human colon Adenocarcinoma cells. Cancer cell proliferation was measured by 3-(4, 5‑dimethylthiazolyl)-2, 5‑diphenyl‑tetrazolium bromide (MTT) a...

background : colorectal cancer is the second cause of mortality in developed countries. the p53gene and some of it's polymorphisms are among the causes for cancer development.the purpose of this study is to evaluate the relationship between the p53 codon 72 polymorphism in colorectal adenocarcinoma specimens compared with controls. materials and methods : we performed a case-control study among...

the aim of this paper is to introduce new methods of colorectal and anus surgeries. it is not a comprehensive paper and just is a summary of issues related to colon surgeries due to intestinal inflammatory diseases (ulcerative colitis and crohn's disease), and anus cancer. ulcerative colitis usually initiates from rectum and then develops upward to colon. there are three methods of surgery...

  Objective(s):Transforming growth factor-β(TGF-β) is involved in colorectal cancer (CRC). The SD-208 acts as an anti-cancer agent in different malignancies via TGF-β signaling. This work aims to show the effect of manipulation of TGF-β signaling on some miRNAs implicated in CRC. Materials and Methods: We investigated the effects of SD-208 on SW-48, a colon adenocarcinoma cell line. The cell li...

background & objectives: colon cancer is currently of high incidence and mortality rate. identifying the factors influencing its prognosis can be very beneficial to its clinical treatment. recent studies have shown that lymph nodes ratio can be considered as an important prognostic factor. the aim of the present study is to investigate the effect of this factor on the prognosis of the patie...

Introduction: In Croatia, about 3,500 patients are diagnosed with a colorectal carcinoma annually. The National Program for Early Detection of Colon Cancer has been implemented in Croatia since 2007. program’s primary goal is todetect colon cancer at an early stage the disease, which should reduce incidence and mortality from cancer. Aim: To determine interest target group participating program...

The chemotherapeutic agent 5-Fluorouracil (5-FU) is the most commonly used drug for patients with advanced colon cancer. However, development of resistance to 5-FU is inevitable in almost all patients. The mechanism by which colon cancer develops 5-FU resistance is still unclear. One recently proposed theory is that cancer stem-like cells underlie colon cancer 5-FU resistance, but the phenotype...